熟地黄治疗绝经后骨质疏松症骨代谢紊乱的“性-效-用”特点探讨  

The property-efficacy-application characteristics of Radix Rehmanniae Preparata in the treatment of bone metabolic disorder of postmenopausal osteoporosis

作　　者：许云腾 段辛威 张欣 黄祖儿 王鼎珍 陈西 周家乐 陈宇航 梁辉强 李西海 XU Yunteng;DUAN Xinwei;ZHANG Xin;HUANG Zuer;WANG Dingzhen;CHEN Xi;ZHOU Jiale;CHEN Yuhang;LIANG Huiqiang;LI Xihai(Academy of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;College of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Fujian Key Laboratory of Integrative Medicine on Geriatrics,Fuzhou 350122,China)

机构地区：[1]福建中医药大学中西医结合研究院,福建福州350122 [2]福建中医药大学中西医结合学院,福建福州350122 [3]福建省中西医结合老年性疾病重点实验室,福建福州350122

出　　处：《中国骨质疏松杂志》2024年第4期577-581,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(82074461)。

摘　　要：绝经后骨质疏松症是一种以骨吸收-骨形成耦联失衡为基本发病机制的全身性代谢性疾病,属中医“骨痿”范畴。基于中医学理论,骨痿为病,以“筋骨肉病在外,肝脾肾虚在内”为主要病机特点。熟地黄之效在脏表现为补肝脾肾,补血滋阴,益精;在体表现为填骨髓、长肌肉、通利血脉。基于现代研究结果,熟地黄治疗绝经后骨质疏松症的作用是多种有效物质共同作用的结果,其可能通过多环节、多靶点调控骨吸收和骨形成的耦联。本文通过梳理国内外文献,从熟地黄的“性-效-用”特点3个维度,结合中医“五脏一体观理论”的认识,归纳及探讨熟地黄治疗绝经后骨质疏松症骨代谢紊乱的作用机制,旨在贯彻中药现代化研究的中西医结合研究范式,为更好地研究熟地黄治疗绝经后骨质疏松症的作用机制和挖掘其临床药用价值提供参考。Postmenopausal osteoporosis is a systemic metabolic disease with the imbalance of bone absorption-bone formation as the basic pathogenesis,which belongs to the category of bone impotence in traditional Chinese medicine.Based on the theory of traditional Chinese medicine,bone impotence is a disease with the main pathogenesis characteristics that muscle and bone disease are external and liver,spleen,and kidney deficiency are internal.The effect of Radix Rehmanniae Preparata on viscera is manifested as tonifying liver,spleen and kidney,tonifying blood and nourishing Yin,and nourishing essence.In the body,it is manifested as filling bone marrow,lengthening muscle,and promoting blood circulation.Based on the result of modern research,the effect of Radix Rehmanniae Preparata in the treatment of postmenopausal osteoporosis is the result of the interaction of many effective substances,which may regulate the coupling of bone resorption and bone formation through multi-links and multi-targets.By combing domestic and foreign literature,,this paper summarizes and discusses the mechanism of Radix Rehmanniae Preparata in anti-postmenopausal osteoporosis bone metabolism disorder from the three dimensions of property-efficacy-application characteristics,combined with the understanding of the five viscera concept theory of traditional Chinese medicine,in order to implement the research paradigm of integrated traditional Chinese and western medicine for the modernization of traditional Chinese medicine,and to provide a reference for better study in the treatment of postmenopausal osteoporosis mechanism of Radix Rehmanniae Preparata and its clinical medicinal value.

关 键 词：绝经后骨质疏松症 骨代谢 熟地黄 性-效-用特点 

分 类 号：R285.6[医药卫生—中药学]