骨质疏松症中的线粒体质量控制  

The role of mitochondrial quality control in osteoporosis

作　　者：齐朋朋 李志超[1] 徐展望[1,3] 王卫国[1,3] QI Pengpeng;LI Zhichao;XU Zhanwang;WANG Weiguo(Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Liaocheng Hospital of Traditional Chinese Medicine,Liaocheng 252000,China;The Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学,山东济南250014 [2]聊城市中医医院,山东聊城252000 [3]山东中医药大学附属医院,山东济南250014

出　　处：《中国骨质疏松杂志》2024年第4期582-587,共6页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金面上项目(82174410);山东省自然科学基金面上项目(ZR2020MH362)。

摘　　要：骨质疏松症是一种常见的代谢性骨疾病,其发病机制与骨内稳态的失衡密切相关。骨内稳态依赖于破骨细胞的骨吸收和成骨细胞的骨形成之间的精确动态平衡。线粒体质量控制,包括线粒体的生物发生、线粒体动力学、氧化应激及线粒体自噬等。线粒体功能被认为在骨稳态平衡中发挥着重要作用。而线粒体功能障碍会被有缺陷的质量控制机制放大,并引起成骨细胞及破骨细胞凋亡或功能异常。线粒体的生物发生、动力学及线粒体自噬能够清除受损线粒体,完成线粒体的更新,对成骨细胞的生成及破骨细胞的分化发挥作用。而骨代谢平衡严重依赖线粒体的氧化应激,过度的氧化应激会加重髓腔环境的炎症状态。线粒体质量控制是恢复线粒体障碍的基石,通过适应性反应促进细胞稳态,保护线粒体结构、形态、数量和功能。因此,本综述详细概述了线粒体质量控制对骨质疏松症的影响,这有助于我们更好地理解骨质疏松症的分子机制以及为后续更多天然药物的开发提供参考。Osteoporosis is a common metabolic bone disease.Its pathogenesis is closely related to the disruption of bone homeostasis.Bone homeostasis relies on the precise dynamic balance between osteoclastic bone resorption and osteoblastic bone formation.Mitochondrial quality control includes mitochondrial biogenesis,mitochondrial dynamics,oxidative stress,and mitophagy.Mitochondrial function is considered to play an important role in maintaining bone homeostasis.Mitochondrial dysfunction,when exacerbated by defective quality control mechanisms,leads to apoptosis or functional abnormalities in osteoblasts and osteoclasts.Mitochondrial biogenesis,dynamics,and mitophagy play a crucial role in clearing damaged mitochondria,renewing the mitochondrial population,and influencing osteoblast differentiation and osteoblastic formation.Furthermore,the balance of bone metabolism critically relies on mitochondrial oxidative stress.Excessive oxidative stress may aggravate the inflammatory state of the medullary cavity environment.Mitochondrial quality control is the cornerstone of restoring mitochondrial disorders,promoting cellular homeostasis through adaptive responses,and protecting mitochondrial structure,morphology,quantity,and function.Therefore,this review comprehensively outlines the effects of mitochondrial quality control on osteoporosis,which contributes to a better understanding of the molecular mechanism of osteoporosis and provides reference for the subsequent development of more natural drugs.

关 键 词：骨质疏松症 线粒体质量控制 成骨细胞 破骨细胞 

分 类 号：R589[医药卫生—内分泌]