破骨细胞相关非编码RNA介导的表观遗传学骨质疏松研究进展  

Research progress on epigenetics mediated by osteoclast-related non-coding RNA in osteoporosis

作　　者：赵瑞 潘静 裴雪冬 宁浩驰 陈海亮 齐雅茜 雷新宇 白金霞 杨钰婷 王薇 张忠文 张浩令 宋志靖 ZHAO Rui;PAN Jing;PEI Xuedong;NING Haochi;CHEN Hailiang;QI Yaqian;LEI Xinyu;BAI Jinxia;YANG Yuting;WANG Wei;ZHANG Zhongwen;ZHANG Haoling;SONG Zhijing(Clinical College of Traditional Chinese Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;School of acupuncture and moxibustion and Massage,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;School of Public Health,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;Institute of Advanced Medicine and Dentistry,University of Science Malaysia,Penang,Malaysia,13200;Dunhuang Key Laboratory of Medicine and Transformation,Ministry of Education,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730000 [2]甘肃中医药大学针灸推拿学院,甘肃兰州730000 [3]甘肃中医药大学公共卫生学院,甘肃兰州730000 [4]马来西亚理科大学高级医学和牙科研究所,马来西亚槟城132005 [5]教育部敦煌医学与转化重点实验室,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2024年第4期588-594,共7页Chinese Journal of Osteoporosis

基　　金：国家自然基金(81960877);甘肃省高等学校创新基金(2021A-076),甘肃省高等学校创新基金(2023A-088);甘肃省科技计划(创新基地和人才计划)项目(21JR7RA561);敦煌医学与转化教育部重点实验室开放基金项目(DHYX20-16);甘肃省中医药研究中心专项开放课题(zyzx-2020-zx10);甘肃省自然基金(21JR1RA267);甘肃省教育科技创新项目(2022A-067);甘肃省自然科学基金(22JR5RA582);甘肃中医药大学研究生创新基金项目。

摘　　要：骨质疏松症(osteoporosis,OP)中的表观遗传修饰可能是遗传和环境因素影响骨质疏松症和骨折风险增加之间的关联机制的体现。microRNA(miRNA)、长非编码RNA(lncRNA)和环状RNA(circRNA)已被证明是表观遗传调节剂,并且参与基因表达的控制,影响多种生物过程,包括骨代谢、骨形成等,是预防和治疗骨质疏松的重要靶标。因此,本文综述了关于miRNA、circRNA和lncRNA介导的与破骨细胞相关的骨质疏松机制的研究近况,拟为破骨细胞功能异常所造成的骨质疏松提供新的研究靶点和诊疗思路。Epigenetic modifications in osteoporosis(OP)may reflect the mechanisms by which genetic and environmental factors influence the association between osteoporosis and increased fracture risk.MicroRNA(miRNA),long non-coding RNA(lncRNA)and circRNA(circRNA)have been proved to be epigenetic modulators and involved in the control of gene expression,affecting a variety of biological processes,including bone metabolism and bone formation,and are important targets for the prevention and treatment of osteoporosis.Therefore,this paper reviews the mechanisms of miRNA,circRNA and lncRNA mediated osteoclast osteoporosis,providing new research targets and treatment ideas for osteoclast dysfunction induced osteoporosis.

关 键 词：MIRNA circRNA lncRNA 破骨细胞 骨质疏松 

分 类 号：R580[医药卫生—内分泌]