线粒体在骨质疏松领域的研究进展  

Research progress of mitochondria in the field of osteoporosis

作　　者：孟世龙 童铭豪 余阳 李威 叶佰盛 史晓林 刘康 MENG Shilong;TONG Minghao;YU Yang;LI Wei;YE Baisheng;SHI Xiaolin;LIU Kang(The Second Clinical Medical College,Zhejiang Chinese Medical University,Hangzhou 310053,China;The Second Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310005,China)

机构地区：[1]浙江中医药大学第二临床医学院,浙江杭州310053 [2]浙江中医药大学附属第二医院,浙江杭州310005

出　　处：《中国骨质疏松杂志》2024年第4期611-614,620,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金项目(82274272,81973884);浙江省中医药重点研究项目(2022ZZ020);浙江省教育厅项目(Y202248737)。

摘　　要：作为一种细胞器,线粒体是有氧呼吸和产生ATP的主要场所,其结构和功能对细胞生命活动十分重要。线粒体结构和功能失衡会导致一系列疾病,如退行性疾病、肌无力、骨质疏松症等。线粒体和骨质疏松症之间存在着密切的联系,它可以通过多种途径参与骨代谢的过程。其中,具体的调节机制主要围绕在氧化磷酸化供能途径、活性氧自由基(ROS)的产生-清除、线粒体动力学等方面,调节线粒体结构和功能是治疗骨质疏松症的潜在途径。因此,本文综述近期线粒体和骨质疏松症的相关研究及最新进展,以期进一步明确两者之间的联系及作用机制,为骨质疏松症的治疗提供新思路。As a kind of organelle,mitochondria are the main places for aerobic respiration and ATP production,and their structure and function are essential for cell life.The imbalance of mitochondrial structure and function can lead to a series of diseases,such as degenerative diseases,myasthenia gravis,osteoporosis,etc.There is a close relationship between mitochondria and osteoporosis,and it can participate in bone metabolism in many ways.Among them,the specific regulatory mechanisms mainly focus on the energy supply pathway of oxidative phosphorylation,the production and clearance of reactive oxygen species(ROS),mitochondrial dynamics,and so on.Regulating the structure and function of mitochondria is a potential way to treat osteoporosis.Therefore,this paper reviews the recent research and latest progress of mitochondria and osteoporosis,in order to further clarify the relationship and mechanism between them,and provide new ideas for the treatment of osteoporosis.

关 键 词：线粒体 氧化磷酸化 活性氧自由基 线粒体动力学 骨质疏松症 

分 类 号：R274.9[医药卫生—中西医结合] R589.5[医药卫生—中医骨伤科学]