辽宁省农村地区成年人群血清亚精胺流行病学分布特征  

Epidemiological distribution of serum spermidine in adults in rural areas of Liaoning province

作　　者：徐嘉慧 白鹤 彭睿恒 李瑞雪 谷翠英 高涵舒 冯文靖 刘敏 赵一凡 孙兆青[6] 邢福国[7] 郑黎强 Xu Jiahui;Bai He;Peng Ruheng;Li Ruixue;Gu Cuiying;Gao Hanshu;Feng Wenjing;Liu Min;Zhao Yifan;Sun Zhaoqing;Xing Fuguo;Zheng Liqiang(Shanghai Jiaotong University School of Medicine,School of Public Health,Shanghai 200025,China;Infectious Disease prevention and Control Center,Hohhot Center for Disease Control and Prevention,Hohhot O10070,China;Occupational Disease Prevention and Control Department,Weifang Municipal Center for Disease Control and Prevention,Weifang 261061,China;School of Public Health,China Medical University,Shenyang 110122,China;Medical Imaging Department of Fenyang College,Shanxi Medical University,Fenyang 032200,China;Department of Cardiology,Shengjing Hospital of China Medical University,Shenyang 10004,China;Institute of Food Science and Technology,Chinese Academy of Agricultural Sciences,Key Laboratory of Quality,Saqfety,Storage and Transportation Control of Agricultural Products,Ministry of Agriculture and Rural Sciences,Bejing 100193,China)

机构地区：[1]上海交通大学医学院公共卫生学院,上海200025 [2]呼和浩特市疾病预防控制中心传染病防制所,呼和浩特010070 [3]潍坊市疾病预防控制中心职业病防制科,潍坊261061 [4]中国医科大学公共卫生学院,沈阳日110122 [5]山西医科大学汾阳学院医学影像系,汾阳032200 [6]中国医科大学附属盛京医院心血管内科,沈阳1110004 [7]中国农业科学院农产品加工研究所农业农村部农产品质量安全收贮运管控重点实验室,北京100193

出　　处：《实用医技杂志》2024年第3期157-162,共6页Journal of Practical Medical Techniques

基　　金：国家自然科学基金面上项目(82073645);吕梁市引进高层次科技人才重点研发项目(2022RC27)。

摘　　要：目的了解辽宁省阜新蒙古自治县农村地区≥35岁成年人血清亚精胺分布状况及影响因素,为进一步开展以血清亚精胺为线索的衰老相关疾病的干预措施提供理论支持。方法于2019年6月至8月,采用分层整群随机抽样方法在中国辽宁省阜蒙县开展流行病学调查,选取年龄在≥35岁且无关键变量缺失的研究对象,采用高效液相色谱-荧光法(HPLC-FLD)检测血清亚精胺含量。采用SPSS22.0软件进行统计分析,描述不同性别、年龄等人口学特征人群的血清亚精胺分布状况及其影响因素。结果研究对象平均年龄为(59±10)岁,其中男性1573名(35.76%),女性为2826名(64.24%)。研究对象血清亚精胺水平为24.8(13.4,50.1)ng/ml,男性35~44岁组和≥65岁组、饮酒、吸烟和超重者的血清亚精胺水平较高(P<0.05)。Spearman相关性分析结果显示,血清亚精胺水平与年龄、舒张压和体质指数呈正相关(r=0.044,0.046,0.051,P<0.05),与高密度脂蛋白胆固醇呈负相关(r=-0.031,P<0.05)。结论辽宁省农村地区≥35岁成人血清亚精胺的分布存在人群差异,且受到性别、年龄、体质指数及行为生活方式等因素的影响。同时,亚精胺与衰老及心血管疾病,尤其是脑卒中密切相关。Objective To understand the distribution characteristics and influencing factors of serum spermidine in adults aged≥35 years in the rural areas of Fumeng county,Liaoning province.Therefore,it provides theoretical support for further intervention measures for aging-related diseases centered on serum spermidine.Methods From June 2019 to August 2019,stratified cluster random sampling was used to conduct an epidemiological investigation in Fumeng County,Liaoning Province,China.Subjects aged≥35 years with no missing key variables were included.Spermidine levels in serum were measured using high-performance liquid chromatography with a fluorescence detector(HPLC-FLD).SPSS 22.0 software was used for statistical analysis to described the distribution and related factors of serum spermidine in populations with different gender,age and other demographic characteristics.Results In total,the mean Mean+SD age of participants was(59.2±10.0)years,including 1573(35.76%)male and 2826 females(64.24%).Serum spermidine levels showed a skewed distribution,with a median(quartile)of 24.8(13.4,50.1)ng/ml,and men,35~44 years and≥65 years,drinkers,smokers,overweight population had higher spermidine levels,the differences were statistically significant(P<0.05).The results of Spearman correlation analysis showed that serum spermidine levels were positively correlated with age,diastolic blood pressure(DBP),and body mass index(BMI)(P<0.05),and negatively correlated with high density lipoprotein(HDL)(P<0.05).Conclusion The distribution of serum spermidine in adults aged 35 and above in rural areas of Liaoning Province was different among different population groups,and was affected by gender,age,body mass index and behavior lifestyle.At the same time,spermidine is closely related to aging and cardiovascular diseases,especially stroke.

关 键 词：亚精胺 横断面研究 分布特征 

分 类 号：R181.3[医药卫生—流行病学]