乙型病毒性肝炎肝硬化患者血清cTNT、LPS水平、FIB-4指数与幽门螺杆菌感染的关系  

Correlation of serum levles of cTNT,LPS and FIB-4 with Helicobacter pylori infection in patients with hepatitis B virus liver cirrhosis

作　　者：陈媛 徐晶 谌翠容 孙振江 周婧玮 CHEN Yuan;XU Jing;CHEN Cui-rong;SUN Zhen-jiang;ZHOU Jing-wei(Xiri Hospital,Hangzhou,Zhejiang 310023,China)

机构地区：[1]杭州市西溪医院肝病科,浙江杭州310023

出　　处：《中华医院感染学杂志》2024年第7期998-1001,共4页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生科技计划基金资助项目(2019KY534)。

摘　　要：目的探讨乙型病毒性肝炎肝硬化(HBV-LC)患者血清心肌肌钙蛋白T(cTNT)、脂多糖(LPS)水平、基因4因子的肝纤维化指数(FIB-4)及与幽门螺杆菌(Hp)感染的关系。方法选取2022年1月-2023年6月杭州市西溪医院收治的72例HBV-LC患者作为研究对象,根据有无Hp感染情况分为感染组42例与未感染组30例,抽取患者空腹静脉血,检测血清cTNT、LPS水平及天门冬氨酸氨基转氨酶(AST)、血小板计数(PLT)、丙氨酸氨基转移酶(ALT)水平,计算FIB-4,并行Hp感染定量检测。比较两组血清学指标及FIB-4指数,Pearson相关性分析血清指标与Hp感染的关系,观察有无Hp感染HBV-LC患者并发症发生情况。结果HBV-LC患者Hp感染率为58.33%(42/72);感染组cTNT、LPS水平及FIB-4指数均高于未感染组(P<0.05);HBV-LC感染组14C呼气试验值与cTNT、LPS水平及FIB-4指数均呈正相关(P<0.05);感染组患者消化性溃疡和门脉高血压胃病发生率为71.43%、42.86%高于未感染组的40.00%和20.00%(P<0.05)。结论HBV-LC患者Hp发生率较高,且与血清cTNT、LPS水平、FIB-4指数变化有关;Hp感染可能会增加HBV-LC患者消化性溃疡和门脉高血压胃病的发生率,建议对HBV-LC患者定期进行Hp监测。OBJECTIVE To explore the correlation between serum levels of cardiac troponin T(cTNT),lipopo-lysaccharide(LPS)and fibrosis index based on the 4 factor(FIB-4)and Helicobacter pylori(Hp)infection in pa-tients with hepatitis B virus liver cirrhosis(HBV-LC).METHODS A total of 72 patients with HBV-LC admitted to Hangzhou Xixi Hospital from Jan 2022 to Jun 2023 were recruited as the research subjects.According to wheth-er Hp infection occurred,they were divided into the infected group(n=42)and the uninfected group(n=30).The fasting venous blood was collected to detect levels of serum cTNT,LPS,aspartate aminotransferase(AST),platelet count(PLT)and alanine aminotransferase(ALT),and FIB-4.Hp infection was quantitatively detec-ted.The serological indexes and FIB-4 index were compared between the two groups.The relationship between ser-um indexes and Hp infection was analyzed by Pearson correlation analysis.The occurrence of complications be-tween HBV-LC patients with and without Hp infection was observed.RESULTS The Hp infection rate of HBV-LC patients was 58.33%(42/72).The levels of cTNT,LPS and FIB-4 index in the infected group were higher than those in the uninfected group(P<0.05).The value of 14 C breath test was positively correlated with cTNT,LPS and FIB-4(P<0.05).The incidence rates of peptic ulcer and portal hypertension in the infection group were 71.43%and 42.86%,higher than those in the non-infection group(40.00%,20.00%,P<0.05).CONCLUSION The incidence of Hp infection is higher in HBV-LC patients,which is related to the changes of ser-um cTNT,LPS and FIB-4.Hp infection may increase the incidence of peptic ulcer and portal hypertensive gastrop-athy in HBV-LC patients.The regular Hp monitoring is recommended for HBV-LC patients.

关 键 词：乙型病毒性肝炎肝硬化 肝纤维化指数 心肌肌钙蛋白T 脂多糖 幽门螺杆菌 感染 

分 类 号：R512.62[医药卫生—内科学]