苯甲酸阿格列汀改善2型糖尿病患者胰岛β细胞功能机制的研究  

Study on the mechanism of improving isletβ-cell function in patients with type 2 diabetes mellitus by Alogliptin benzoate

作　　者：杨曦 张璞 马竞轩 孙梦楚 李立琴[1] 王君[1] YANG Xi;ZHANG Pu;MA Jingcuan(Department of Endocrinolog,Baoding NO.1 Central Hospital,Baoding 071000,China)

机构地区：[1]保定市第一中心医院内分泌科

出　　处：《中国糖尿病杂志》2024年第3期173-176,共4页Chinese Journal of Diabetes

基　　金：河北省医学适用技术跟踪项目(GZ2022088)。

摘　　要：目的探讨苯甲酸阿格列汀(Alog)通过自噬通路改善T2DM患者胰岛β细胞功能的机制。方法选取2021年12月至2022年10月于保定市第一中心医院内分泌科治疗的新诊断T2DM患者80例,随机分为二甲双胍治疗组(Met)和Met联合Alog治疗组(Met+Alog),每组各40例。比较两组治疗12周前后BMI、WHR、FPG、HbA1c、Atg7、Beclin-1等差异。结果治疗后两组Atg7、Beclin-1升高(P<0.05),FPG、HbA1c、胰岛素抵抗指数降低(P<0.05)。Met+Alog组治疗后Atg7、Beclin-1、HDL-C高于Met组(P<0.05)。Pearson相关分析显示,Atg7与BMI、FPG、HbA1c呈负相关(P<0.05);Beclin-1与HDL-C呈正相关(P<0.05),与BMI、FPG、HbA1c、TG呈负相关(P<0.05)。多元线性回归分析显示,BMI是Atg7的影响因素,BMI、HDL-C是Beclin-1的影响因素。结论Alog可能通过上调T2DM患者自噬相关因子Atg7和Beclin-1表达,改善胰岛β细胞功能。Objective To investigate the effect of Alogliptin benzoate on the serum autophagy markers in type 2 diabetes mellitus(T2DM)patients.Methods Eighty newly diagnosed T2DM patients who visited the Department of Endocrinology in Baoding No.1 Central Hospital from December 2021 to October 2022 were randomly divided into a group treated with Metformin(Met group,n=40)and a group treated with Met and Alog(Met+Alog group,n=40).The differences in BMI,WHR,FPG,HbAic,Atg7 and Beclin-1 between two groups before and after 12 weeks of treatment were compared.Results After treatment,the levels of Atg7 and Beclin-1 increased in both groups(P<0.05),while FPG,HbAic and HOMA-IR decreased(P<0.05).After treatment,Atg7,Beclin-1 and HDL-C in Met+Alog group were higher than those in Met group(P<0.05).Pearson correlation analysis showed that Atg7 was negatively correlated with BMI,FPG and HbAic(P<0.05);Beclin-1 was positively correlated with HDL-C(P<0.05),and negatively correlated with BMI,FPG,HbAic,and TG(P<0.05).Meta linear regression analysis showed that BMI was the influencing factor of Atg7,while BMI and HDL-C were the influencing factors of Beclin-1.Conclusion Alogliptin benzoate may improve isletβcell function by up-regulating the expression of autophagy related factors Atg7 and Beclin-1 in patients with T2DM.

关 键 词：苯甲酸阿格列汀 糖尿病 2型 自噬 胰岛Β细胞 

分 类 号：R587.1[医药卫生—内分泌]