16种岭南特色道地药材对肺炎链球菌的抑菌作用研究  

Study on the antibacterial effect of 16 kinds of Lingnan genuine medicinal materials on Streptococcus pneumoniae

作　　者：汤曼莉 章晶 吴愫青 TANG Manli;ZHANG Jing;WU Suqing(Zhuhai Institute of Food and Drug Control Postcode,Zhuhai Guangdong,519090,China)

机构地区：[1]珠海市食品药品检验所药品室,广东珠海519090

出　　处：《质量安全与检验检测》2024年第2期87-90,共4页QUALITY SAFETY INSPECTION AND TESTING

摘　　要：研究16种岭南特色道地药材对肺炎链球菌的体外抑菌活性。以肺炎链球菌为受试菌,采用24孔板培养法测定16种岭南特色道地药材醇提物的最低抑菌浓度(MIC)和最低杀菌浓度(MBC)。结果显示,16种岭南特色药材中有11种对肺炎链球菌有抑菌性,分别为:火炭母、桂枝、长萼堇菜、岗梅、广藿香、扁桃斑鸠菊、破布叶、一点红、狗肝菜、三桠苦、地胆草。其中,长萼堇菜、广藿香、扁桃斑鸠菊、狗肝菜、三桠苦、地胆草的醇提物表现出较强的抑菌活性。部分岭南特色道地药材的乙醇提取物对肺炎链球菌具有良好的抑菌作用。To study the in vitro antibacterial activity of 16 unique Lingnan medicinal herbs against Streptococcus pneumoniae.Using Streptococcus pneumoniae as the test strain,the minimum inhibitory concentration(MIC)and minimum bactericidal concentration(MBC)of 16 authentic Lingnan medicinal herbs were determined using a 24 well plate culture method.The results showed that among the 16 Lingnan characteristic medicinal herbs,11 have antibacterial activity against Streptococcus pneumoniae,including Persicaria chinensis(L.)H.Gross,Cinnamomum cassia Presl,Viola inconspicua Blume,Radix Ilicis Asprellae,Pogostemon cablin,Vernonia amygdalina Delile,Microcos paniculata,Emilia sonchifolia,Dicliptera chinensis,Evodia lepta and Elephantopus scaber.Among them,the ethanol extracts of Viola inconspicua,Pogostemon cablin,Vernonia amygdalina Delile,Dicliptera chinensis,Evodia lepta,and Elephantopus scaber showed strong antibacterial activity.The ethanol extracts of some unique Lingnan medicinal herbs have good antibacterial effects on Streptococcus pneumoniae.

关 键 词：道地药材 肺炎链球菌 抑菌作用 最低抑菌浓度(MIC) 最低杀菌浓度(MBC) 

分 类 号：R932[医药卫生—生药学]