FAM83A基因及其调控因子对肺腺癌发生和发展机制研究  

Study on the Mechanism of FAM83A Gene and Its Regulators on the Development and Progression of Lung Adenocarcinoma

作　　者：呼思乐 白慧 李前忠[1] HU Sile;BAI Hui;LI Qianzhong(School of Physical Science and Technology,Inner Mongolia University,Hohhot O10021,China)

机构地区：[1]内蒙古大学物理科学与技术学院,呼和浩特010021

出　　处：《内蒙古大学学报（自然科学版）》2024年第2期160-172,共13页Journal of Inner Mongolia University：Natural Science Edition

基　　金：国家自然科学基金资助项目(32160216,62361047)。

摘　　要：FAM83家族基因在多种癌症中起致癌作用,本文以FAM83A为家族基因的代表进行研究。FAM83A在多种癌症中起到致癌作用,尤其在肺腺癌中的作用最为显著。本文以TCGA数据库中594条肺腺癌数据为基础,分析FAM83A在肺腺癌中的致癌原理。结果显示FAM83A高表达对肺腺癌的发生有着显著影响。对与FAM83A表达相关的RNA和甲基化位点进行分析,最终得到了4个核心目标lncRNA以及18个与FAM83A表达显著相关的甲基化位点。FAM83A和它共表达基因进行组织和功能富集分析,结果显示FAM83A主要富集在肺部、乳腺和结肠组织以及免疫细胞和非小细胞肺癌相关通路。这些结果表明,FAM83A以及其调控元件共同对肺腺癌的发生和发展产生影响,并可能成为肺腺癌诊断和治疗过程中的一个潜在生物标志物。The FAM83 gene family plays an oncogenic role in a variety of cancers,and we used FAM83A as a representative to explore its oncogenic mechanism.FAM83A is an oncogene in many cancers,especially in LUAD(lung adenocarcinoma).In this paper,we downloaded 594 LUAD data from TCGA database to analyze the oncogenic principle of FAM83A in LUAD.The results showed that the high expression of FAM83A has a significant effect on the development of lung adenocarcinoma and the progression from stage T1 to stage T2.By analyzing RNAs and DNA methylation level associated with FAM83A expression,we found four target lncRNAs and 18 methylation sites that were significantly associated with FAM83A expression.Tissue enrichment and functional enrichment analysis of FAM83A and its co-expressed genes showed that FAM83A was mainly enriched in lung,breast and colon tissues as well as immune cells and non-small cell lung cancer related pathways.These results indicated that FAM83A may be a potential biomarker in the prevention and treatment of lung adenocarcinoma.

关 键 词：肺腺癌 差异非编码RNA ceRNA网络 甲基化分析 

分 类 号：Q61[生物学—生物物理学]