New pimarane diterpenoids with antibacterial activity from fungus Arthrinium sp.ZS03  

作　　者：ZHAO Songfeng JING Ziwei 

机构地区：[1]Department of Pharmacy,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China

出　　处：《Chinese Journal of Natural Medicines》2024年第4期356-364,共9页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.82003956);the Henan Young Elite Scientists Sponsorship Program(No.2023HYTP032)。

摘　　要：A comprehensive chemical study of the endophytic fungus Arthrinium sp. ZS03, associated with Acorus tatarinowii Schott, yielded eleven pimarane diterpenoids (compounds 1–11), including seven novel compounds designated arthrinoids A–G (1–7). The determination of their structures and absolute configurations was achieved through extensive spectroscopic techniques, quantum chemical calculations of electronic circular dichroism (ECD), and single-crystal X-ray diffraction analysis. Furthermore, 7 demonstrated inhibitory activity against Klebsiella pneumoniae, comparable to the reference antibiotic amikacin, with a minimum inhibitory concentration (MIC) of 8 μg·mL^(−1).

关 键 词：Arthrinium sp.ZS03 Pimarane diterpenoids Structural elucidation Antibacterial activity 

分 类 号：R284.1[医药卫生—中药学]