不同浓度聚维酮碘溶液预防异基因造血干细胞移植患者肛周感染的效果研究  

Effects of different concentrations of povidone iodine solution on the prevention of perianal infection in patients with allogeneic hematopoietic stem cell transplantation

作　　者：胡伟[1] 郭秀娟[1] 张蓓蓓[1] 宋岩 徐晓东[1] 王蕾 王佳婷 Hu Wei;Guo Xiujuan;Zhang Beibei;Song Yan;Xu Xiaodong;Wang Lei;Wang Jiating(Hematology Department of Peking University People′s Hospital,Beijing100044,China)

机构地区：[1]北京大学人民医院血液科,北京100044

出　　处：《中国实用护理杂志》2024年第12期889-893,共5页Chinese Journal of Practical Nursing

基　　金：北京大学人民医院研究与发展基金(RDN2018-18)。

摘　　要：目的明确不同浓度聚维酮碘溶液预防异基因造血干细胞移植患者肛周感染的效果,为临床开展聚维酮碘坐浴的配制浓度提供依据。方法采用便利抽样法,行类实验研究,选取2019年1月至2020年12月在北京大学人民医院血液科无菌层流病房行异基因造血干细胞移植的727例患者为研究对象,按照入院时间分组,2019年1—12月的患者为对照组358例,2020年1—12月的患者为试验组369例,对照组采用0.0005%聚维酮碘溶液进行坐浴,试验组采用0.005%聚维酮碘溶液进行坐浴,观察并比较2组患者肛周感染发生情况。结果对照组男222例,女136例,年龄32.0(23.0,44.0)岁,试验组男219例,女150例,年龄31.0(21.0,44.0)岁。试验组肛周感染发生率为16.3%(60/369),低于对照组的23.2%(83/358),差异有统计学意义(χ^(2)=5.51,P<0.05)。2组肛周感染严重程度比较差异无统计学意义(P>0.05)。结论坐浴时提高聚维酮碘溶液浓度可降低造血干细胞移植患者肛周感染的发生率,护理人员可在造血干细胞移植患者中应用该方法,以预防患者肛周感染的发生。Objective To clarify the effectiveness of using different concentrations of iodophor solution sitz baths to prevent perianal infection in patients undergoing allogeneic hematopoietic stem cell transplantation,and provide a basis for the preparation concentration of iodophor sitz baths in clinical practice.Methods A convenience sampling method was used to conduct a comparative experimental study.727 patients who underwent allogeneic hematopoietic stem cell transplantation in the sterile laminar flow ward of Hematology Department of Peking University People′s Hospital from January 2019 to December 2020 were selected as the study subjects.They were divided into an experimental group of 369 patients admitted from January to December,2020 and a control group of 358 patients admitted from January to December,2019 based on their admission time.The experimental group used 0.005%iodophor solution for hip baths,while the control group used 0.0005%iodophor solution for sitz baths.Observed and compared the occurrence of perianal infections between two groups of patients.Results There were 222 males and 136 females in the control group,aged 32.0(23.0,44.0)years old,and 219 males and 150 females in the experimental group,aged 31.0(21.0,44.0)years old.The incidence of perianal infection in the experimental group was 16.3%(60/369),which was lower than the control group′s 23.2%(83/358),and the difference was statistically significant(χ^(2)=5.51,P<0.05).There was no statistically significant difference in the severity of perianal infection between the two groups(P>0.05).Conclusions Increased concentration of iodophor solution for sitz bath can reduce the incidence of perianal infection in patients with hematopoietic stem cell transplantation.Nursing staff can apply this method in hematopoietic stem cell transplant patients to prevent the occurrence of perianal infection in patients.

关 键 词：造血干细胞移植 聚维酮碘溶液 无菌层流病房 肛周感染 坐浴 

分 类 号：R457.7[医药卫生—治疗学] R657.1[医药卫生—临床医学]