有创-无创序贯机械通气治疗重症肺炎合并呼吸衰竭的效果  

Effect of Invasive-noninvasive Sequential Mechanical Ventilation in the Treatment of Severe Pneumonia Combined with Respiratory Failure

作　　者：关丽君 卢玉婷 张辉[1] 高玉韶[1] Guan Lijun;Lu Yuting;Zhang Hui;Gao Yushao(Intensive Care Unit,Jiangmen Central Hospital,Jiangmen 529000,Guangdong Province,China)

机构地区：[1]江门市中心医院重症医学科,广东江门529000

出　　处：《中外医药研究》2024年第5期39-41,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析有创-无创序贯机械通气治疗重症肺炎合并呼吸衰竭的效果。方法:选取2021年10月—2023年3月江门市中心医院收治的重症肺炎合并呼吸衰竭患者66例为研究对象,通过随机编号抽签分为对照组和试验组,各33例。对照组采取有创机械通气治疗,试验组采取有创-无创序贯机械通气治疗。比较两组血气指标[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))]、炎性指标[白细胞介素-6(IL-6)、C反应蛋白(CRP)]、总机械通气时间、首次脱机成功率。结果:脱机后24、48h,试验组PaO_(2)、PaCO_(2)水平与脱机前比较,差异无统计学意义(P>0.05);脱机后24、48h,对照组PaO_(2)水平低于脱机前,差异有统计学意义(P<0.05);脱机后48h,对照组PaCO_(2)水平高于脱机前,差异有统计学意义(P<0.05)。脱机后72h,两组IL-6、CRP水平降低,试验组IL-6、CRP水平低于对照组,差异有统计学意义(P<0.05)。试验组总机械通气时间短于对照组,首次脱机成功率高于对照组,差异有统计学意义(P<0.05)。结论:有创-无创序贯机械通气治疗重症肺炎合并呼吸衰竭的效果较好,能有效改善患者的血氧状态,减轻炎性反应,缩短机械通气时间,提高脱机成功率。Objective:To analyze the effect of invasive-noninvasive sequential mechanical ventilation in the treatment of severe pneumonia combined with respiratory failure.Methods:Sixty-six patients with severe pneumonia combined with respiratory failure admitted to Jiangmen Central Hospital from October 2021 to March 2023 were selected for the study,and were divided into the control group and the experimental group,each with thirty-three cases,by random numbered draw.The control group was treated with invasive mechanical ventilation,and the experimental group was treated with invasive-noninvasive sequential mechanical ventilation.Blood gas indexes[partial pressure of arterial oxygen(PaO_(2)),partial pressure of arterial carbon dioxide(PaCO_(2))],inflammatory indexes[interleukin-6(IL-6),C-reactive protein(CRP)],total mechanical ventilation time,and the success rate of the first time off the machine were compared between the two groups.Results:24 and 48 h after off-boarding,the PaO_(2) and PaCO_(2) levels of the test group were compared with those before off-boarding,and the difference was not statistically significant(P>0.05);at 24 and 48 h after off-boarding,the PaO_(2) level of the control group was lower than that before off-boarding,and the difference was statistically significant(P<0.05);48 h after off-boarding,the PaCO_(2) level of the control group was higher than that before off-boarding,and the difference was statistically significant(P<0.05).72 h after off-boarding,the levels of IL-6 and CRP in the two groups decreased,and the levels of IL-6 and CRP in the experimental group were lower than those in the control group,and the difference was statistically significant(P<0.05).The total mechanical ventilation time of the experimental group was shorter than that of the control group,and the success rate of the first time off the machine was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:Invasive-noninvasive sequential mechanical ventilation is more effective in

关 键 词：有创-无创序贯机械通气 重症肺炎 呼吸衰竭 炎性反应 

分 类 号：R563[医药卫生—呼吸系统]