克拉霉素联合替硝唑治疗小儿胃炎的临床效果  

Clinical Effect of Clarithromycin Combined with Tinidazole in the Treatment of Pediatric Gastritis

作　　者：袁雪荣 Yuan Xuerong(Heze Yuncheng County Liji Town Center Health Hospital,Heze 274712,Shandong Province,China)

机构地区：[1]菏泽市郓城县李集镇中心卫生院,山东菏泽274712

出　　处：《中外医药研究》2024年第5期60-62,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:观察克拉霉素联合替硝唑治疗小儿胃炎的临床效果。方法:选取2022年2月—2023年2月菏泽市郓城县李集镇中心卫生院收治的胃炎患儿98例为研究对象,随机分为研究组和对照组,各49例。研究组采用克拉霉素联合替硝唑治疗,对照组采用阿莫西林联合甲硝唑治疗。比较两组症状好转时间、胃分泌指标、炎性因子水平、不良反应发生情况。结果:研究组胃部嗳气反酸、胃痛、胃胀、口苦口干症状好转时间短于对照组,差异有统计学意义(P<0.001)。治疗前,两组胃蛋白酶原、胃泌素17水平比较,差异无统计学意义(P>0.05);治疗后,两组胃蛋白酶原、胃泌素17水平高于治疗前,研究组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)以及超敏C反应蛋白(hs-CRP)水平比较,差异无统计学意义(P>0.05);治疗后,两组IL-6、TNF-α、hs-CRP水平低于治疗前,研究组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:克拉霉素联合替硝唑治疗小儿胃炎的临床效果较好,可改善临床症状及胃分泌指标,减轻炎性反应,安全性高。Objective:To observe the clinical effect of clarithromycin combined with tinidazole in the treatment of pediatric gastritis.Methods:Selected ninety-eight cases of children with gastritis admitted to Heze Yuncheng County Liji Town Center Health Hospital from February 2022 to February 2023 as the study object,randomly divided into the study group and the control group,each with forty-nine cases.The study group was treated with clarithromycin combined with tinidazole,and the control group was treated with amoxicillin combined with metronidazole.The two groups were compared in terms of symptom improvement time,gastric secretion indexes,inflammatory factor levels,and the occurrence of adverse reactions.Results:The improvement time of gastric belching and acid regurgitation,gastric pain,gastric distension,bitter mouth and dry mouth symptoms in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.001).Before treatment,the levels of pepsinogen and gastrin 17 in the two groups were compared,and the difference was not statistically significant(P>0.05);after treatment,the levels of pepsinogen and gastrin 17 were higher than those before treatment in both groups,and the study group was higher than the control group,and the difference was statistically significant(P<0.05).Before treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α),and hypersensitive C-reactive protein(hs-CRP)were compared between the two groups,and the difference was not statistically significant(P>0.05);after treatment,the levels of IL-6,TNF-α,and hs-CRP were lower than those before treatment in both groups,and the study group was lower than the control group,and the difference was statistically significant(P<0.05).Compared the incidence rates of adverse reactions in the two groups,the difference was not statistically significant(P>0.05).Conclusion:Clarithromycin combined with tinidazole has a better clinical effect in the treatment of pediatric gastritis,which can improve

关 键 词：小儿胃炎 克拉霉素 替硝唑 不良反应 

分 类 号：R725.7[医药卫生—儿科]