甲泼尼龙琥珀酸钠不同给药方式治疗突发性聋的临床效果  

Clinical Effects of Different Administration Mode of Methylprednisolone Sodium Succinate in the Treatment of Sudden Deafness

作　　者：韦节秀 路磊[1] 谢双[1] 李涛[1] Wei Jiexiu;Lu Lei;Xie Shuang;Li Tao(Zibo Linzi District People's Hospital,Zibo 255400,Shandong Province,China)

机构地区：[1]淄博市临淄区人民医院,山东淄博255400

出　　处：《中外医药研究》2024年第5期66-68,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨甲泼尼龙琥珀酸钠不同给药方式治疗突发性聋的临床效果。方法:选取2018年1月—2023年10月淄博市临淄区人民医院收治的突发性聋患者120例作为研究对象,采用随机数字表法分为鼓室内注射组与静脉滴注组,各60例。静脉滴注组给予甲泼尼龙琥珀酸钠静脉滴注,鼓室内注射组给予甲泼尼龙琥珀酸钠鼓室内注射。比较两组治疗前后听阈、疗效、不良反应发生情况。结果:治疗前,两组1、2、4kHz听阈比较,差异无统计学意义(P>0.05);治疗后15d,两组1、2、4kHz听阈低于治疗前,鼓室内注射组低于静脉滴注组,差异有统计学意义(P<0.05)。鼓室内注射组治疗总有效率高于静脉滴注组,差异有统计学意义(P=0.027)。静脉滴注组胃肠道反应、水肿发生率高于鼓室内注射组,耳痛发生率低于鼓室内注射组,差异有统计学意义(P<0.05);两组眩晕、鼓膜穿孔发生率比较,差异无统计学意义(P>0.05)。结论:相比于静脉滴注,鼓室内注射甲泼尼龙琥珀酸钠可有效改善患者听力情况,促进患者听力恢复,但是治疗期间可能引起耳痛、鼓膜穿孔等不良反应,治疗时需采取有效措施。Objective:To explore the clinical effects of different administration modes of methylprednisolone sodium succinate in the treatment of sudden deafness.Methods:One hundred and twenty cases of patients with sudden deafness admitted to Zibo Linzi District People's Hospital from January 2018 to October 2023 were selected as the study subjects,and were divided into intratym⁃panic injection group and intravenous drip group,each of which consisted of sixty cases by using the randomized numerical table method.The intravenous drip group was given methylprednisolone sodium succinate intravenous drip,and the intratympanic injec⁃tion group was given methylprednisolone sodium succinate intratympanic injection.Hearing threshold,therapeutic efficacy and oc⁃currence of adverse reactions were compared between the two groups before and after treatment.Results:Before treatment,there was no statistically significant difference between the 1,2 and 4 kHz hearing thresholds of the two groups(P>0.05);15 d after treatment,the 1,2 and 4 kHz hearing thresholds of the two groups were lower than that before treatment,and the intratympanic in⁃jection group was lower than that of the intravenous drip group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the intratympanic injection group was higher than that in the intravenous drip group,and the differ⁃ence was statistically significant(P=0.027).The incidence of gastrointestinal reaction and edema in the intravenous drip group was higher than that in the intratympanic injection group,and the incidence of earache was lower than that in the intratympanic in⁃jection group,and the difference was statistically significant(P<0.05);there was no statistically significant difference when com⁃paring the incidence of vertigo and tympanic membrane perforation in the two groups(P>0.05).Conclusion:Compared with intra⁃venous drip,intratympanic injection of methylprednisolone sodium succinate can effectively improve the patients'hearing condi⁃

关 键 词：突发性聋 甲泼尼龙琥珀酸钠 鼓室内注射 

分 类 号：R764.437[医药卫生—耳鼻咽喉科]