基于β-环糊精主客体识别的胆固醇吸附剂的研究进展  

Progress of Cholesterol Adsorbents Based on Host-Guest Recognition Utilizingβ-Cyclodextrin

作　　者：鲁炯呈 黄雯 贾永光 蔡莉莉 LU Jiong-cheng;HUANG Wen;JIA Yong-guang;CAI Li-li(School of Materials Science and Engineering,South China University of Technology,Guangzhou 510641,China;Guangzhou Huali Science and Technology Vocational College,Guangzhou 511325,China)

机构地区：[1]华南理工大学材料科学与工程学院,广州510641 [2]广州华立科技职业学院,广州511325

出　　处：《离子交换与吸附》2024年第1期37-47,共11页Ion Exchange and Adsorption

基　　金：国家自然科学基金(基金号22075087)。

摘　　要：胆固醇是人体内必不可少的一种脂质分子,在人体的代谢过程中发挥着至关重要的作用。机体内胆固醇淤积往往与动脉粥样硬化、C型尼曼匹克氏症等疾病的发生密切相关,但现今药物的副作用以及禁忌症给临床治疗带来了诸多不便。β-环糊精是一种能够识别胆固醇的天然大环分子,其与胆固醇之间的主客体相互识别作用可用于胆固醇的特异性吸附与清除。在本综述中,我们总结了近年来基于β-环糊精主客体识别作用的胆固醇吸附剂的制备方法、设计原理及研究现状,展现了β-环糊精作为功能吸附基团在治疗高胆固醇相关疾病应用上的巨大潜力。Cholesterol is an essential lipid molecule in the human body and plays a crucial role in the metabolic process.Cholesterol accumulation in the body is often closely related to atherosclerosis,Niemann Pick's disease type C and other diseases,but its clinical treatment suffers from the inconvenience arising from the side effects and contraindications of currently available drugs.β-Cyclodextrin is a kind of natural cyclic molecules and can recognize cholesterol.The host-guest interaction betweenβ-cyclodextrin and cholesterol can be used for selective adsorption and clearance of cholesterol.In this review,we summarize the recent progress of the preparation methods,design principles and research status of cholesterol adsorbents based onβ-cyclodextrin's host-guest interaction,and demonstrate thatβ-cyclodextrin exhibits great potential as a functional adsorbent for the treatment of high-leveled cholesterol-related diseases.

关 键 词：环糊精 胆固醇 主客体相互作用 吸附剂 

分 类 号：O647.3[理学—物理化学]