大孔树脂吸附裸花紫珠苯乙醇苷的动力学与热力学研究  

Adsorption Kinetics and Thermodynamics of Phenylethanoid Glycosides from Callicarpa Nudiflora by Macroporous Resins

作　　者：潘章超 邹明明 王勇[1] PAN Zhang-chao;ZOU Ming-ming;WANG Yong(Key Laboratory of Tropical Translational Medicine of Ministry of Education,Hainan Provincial Key Laboratory for Research and Development on Tropical Herbs,School of Pharmacy,Hainan Medical University,Haikou 571199,China)

机构地区：[1]海南医学院药学院,海南省热带药用植物研究开发重点实验室,热带转化医学教育部重点实验室,海口571199

出　　处：《离子交换与吸附》2024年第1期72-80,共9页Ion Exchange and Adsorption

基　　金：海南省自然科学基金(基金号813192)。

摘　　要：考察不同类型大孔树脂吸附裸花紫珠苯乙醇苷的动力学与热力学特性,为该类化合物的分离纯化提供参考。以吸附率、解吸率为综合评价指标,通过静态吸附-解吸附试验从6种大孔树脂中筛选出最适合纯化裸花紫珠苯乙醇苷类成分的大孔树脂类型,建立大孔树脂纯化裸花紫珠苯乙醇苷的吸附动力学模型和等温吸附模型,探究其吸附过程。根据初步筛选结果,选择SP-827、SP-207和X-5型大孔树脂进一步考察,3种树脂具有大致一样的吸附过程:0~60 min为快速吸附阶段;60~360 min为缓慢吸附阶段;360~1080 min为吸附平衡阶段。准二级动力学方程能很好地模拟3种型号的大孔树脂对裸花紫珠苯乙醇苷的吸附动力学过程,吸附速率受液膜扩散和颗粒内扩散共同影响;Langmuir模型和Freundlich模型都能较好地拟合吸附等温线数据,3种类型的大孔树脂对裸花紫珠苯乙醇苷都具有良好的吸附性能,吸附过程属于“优惠吸附”。动力学模型与热力学模型都能很好地拟合这3种类型大孔树脂纯化裸花紫珠苯乙醇苷的吸附过程,其中国产树脂X-5可以用来代替进口树脂SP-825或SP-207用于裸花紫珠苯乙醇苷类成分的分离和纯化研究,也是纯化裸花紫珠苯乙醇苷类成分性能良好的树脂。The kinetics and thermodynamics for the adsorption of phenylethanoid glycosides(PhGs)from Callicarpa nudiflora(C.nudiflora)by different types of macroporous resins were investigated,and thereby guiding the separation and purification of such compounds.With adsorption and desorption ratio as indexes,optimal macroporous resins for purification of PhGs were selected from six categories by estimating the static adsorption and desorption features.This also allows for establishment of adsorption kinetics and adsorption isotherm models for PhGs to investigate their adsorption processes.According to the preliminary screening results,resins SP-825,SP-207,and X-5 were utilized for further investigation,and they exhibited comparable adsorption processes for PhGs.The three resins showed the fast adsorption,slow adsorption and equilibrium adsorption stages during the periods of 0~60 min,60~360 min,and after 360 min,respectively.Adsorption dynamics was well simulated by quasi-second-order equation for three macroporous resins,and adsorption rate was simultaneously controlled by liquid film diffusion and intraparticle diffusion.Equilibrium adsorption data were well fitted by Langmuir and Freundlich isotherm equations.PhGs were efficiently adsorbed by the three kinds of resins with favorable adsorption characteristics.The adsorption process of PhGs from C.nudiflora by the three types of macroporous resins can be fitted by both kinetic and thermodynamic models.Experimental results demonstrate that the domestic resin X-5 can be used to replace the imported resin SP-825 or SP-207 for the separation and purification study of C.nudiflora with good purification performance.

关 键 词：裸花紫珠 苯乙醇苷 大孔吸附树脂 吸附动力学 吸附热力学 

分 类 号：O647[理学—物理化学]