健胃消食口服液联合双岐杆菌三联活菌颗粒治疗小儿功能性消化不良的效果观察  

Observation on effect of Jianwei Xiaoshi oral liquid combined with bifidobacterium triple live bacteria granules in treatment of children with functional dyspepsia

作　　者：徐远幸 王登 赵婷婷 Xu Yuanxing;Wang Deng;Zhao Tingting(Department of Pediatrics,Guangji Angiocardiopathy Hospital,Zhumadian,Henan 463000,China;Department of Intensive Care Unit,Guangji Angiocardiopathy Hospital,Zhumadian,Henan 463000,China)

机构地区：[1]驻马店广济心血管病医院儿科,河南驻马店463000 [2]驻马店广济心血管病医院ICU,河南驻马店463000

出　　处：《齐齐哈尔医学院学报》2024年第7期640-643,共4页Journal of Qiqihar Medical University

摘　　要：目的 观察健胃消食口服液联合双岐杆菌三联活菌颗粒治疗小儿功能性消化不良的效果。方法 选择2021年8月—2023年8月本院收治的106例功能性消化不良患儿作为研究对象,通过随机数表法均分为西药组和观察组。西药组用水冲服双岐杆菌三联活菌颗粒治疗,观察组在西药组基础上加用健胃消食口服液治疗。比较两组临床疗效、症状改善情况和不良反应发生情况,治疗前后的胃肠激素和脑肠肽水平、胃电图指标。结果 观察组的总有效率(98.11%)较西药组(79.25%)明显更高,差异有统计学意义(P<0.05)。治疗后两组功能性消化不良生存质量表(FDDQL)评分均提高明显,观察组较西药组明显更高;观察组腹胀、厌食、嗳气、反酸改善时间较西药组明显更短,差异有统计学意义(P<0.05)。治疗后两组血管活性肠肽(VIP)、胃泌素(GAS)、生长抑素(SS)水平均降低明显,观察组较西药组明显更低;N神经肽Y(NPY)、胃动素(MTL)水平均提升明显,观察组较西药组明显更高,差异有统计学意义(P<0.05)。治疗后两组平均收缩波频率(MFC)、收缩波幅值(AC)均提高明显,观察组较西药组明显更高,差异有统计学意义(P<0.05)。西药组和观察组不良反应发生率分别为5.66%和7.55%,差异无统计学意义(P>0.05)。结论 小儿功能性消化不良应用健胃消食口服液联合双岐杆菌三联活菌颗粒治疗效果明显,显著改善患儿临床症状、胃肠激素和脑肠肽水平、胃电图指标,且安全性较高。Objective To observe the effect of Jianwei Xiaoshi oral liquid combined with bifidobacterium triplet bacteria granules on functional dyspepsia in children.Methods A total of 106 children with functional dyspepsia who were treated in our hospital from August 2021 to August 2023 were selected as the study objects and they were divided into the western medicine group and the observation group according to random number table method.Patients in western medicine group took bifidobacterium triple live bacteria granules with water,and the observation group was treated with Jianwei Xiaoshi oral liquid on the basis of Western medicine group.The clinical efficacy,symptom improvement and adverse reactions were compared between the two groups,as well as the levels of gastrointestinal hormones,brain-intestinal peptides and electrogastrogram before and after treatment.Results The total effective rate of observation group(98.11%) was significantly higher than that of western medicine group(79.25%),and the difference was statistically significant(P<0.05).After treatment,functional digestive disorders quality of life questionnaire(FDDQL) scores in both groups were significantly improved,and the observation group was significantly higher than the western medicine group.The improvement time of abdominal distension,anorexia,belching and acid reflux in the observation group was significantly shorter than that in the western medicine group,and the differences were statistically significant(P<0.05).After treatment,the levels of vasoactive intestinal peptide(VIP),gastrin(GAS) and somatostatin(SS) in both groups were significantly reduced,and the observation group was significantly lower than the western medicine group.The levels of N neuropeptide Y(NPY) and motilin(MTL) in the observation group were significantly higher than those in the western medicine group,with statistical significance(P<0.05).After treatment,mean frequency of contraction wave(MFC) and amplitude of contraction wave(AC) were significantly increased in both groups,and

关 键 词：健胃消食口服液 双岐杆菌三联活菌颗粒 功能性消化不良 胃电图 

分 类 号：R725.7[医药卫生—儿科]