儿童急性胰腺炎临床特征及重症危险因素分析  

Analysis of Clinical Features of Pediatric Acute Pancreatitis and Risk Factors for Severe Disease

作　　者：石璐璐 于静[1] SHI Lulu;YU Jing(Gastroenterology Department,Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital Zhengzhou Children’s Hospital,Zhengzhou 450018,China)

机构地区：[1]郑州大学附属儿童医院、河南省儿童医院郑州儿童医院消化内科,河南郑州450018

出　　处：《河南医学研究》2024年第8期1369-1373,共5页Henan Medical Research

摘　　要：目的探讨儿童急性胰腺炎(AP)临床特征及重症危险因素。方法本研究为回顾性研究,选取郑州大学附属儿童医院2021年1月至2022年6月诊断为AP的72例住院患儿为研究对象。按照NASPGHAN指南AP分级标准,将研究对象分为轻症AP组(41例)和重症AP组(31例),其中重症AP组包含中重症AP和重症AP。通过病历资料检索,收集研究对象一般临床资料、实验室检查结果、并发症情况、治疗方式等信息,应用logistic回归分析重症AP的危险因素。结果轻症AP组和重症AP组性别、病因、入院时C反应蛋白、血清白蛋白、血清尿素氮和血清Ca 2+比较,差异有统计学意义(P<0.05)。入院时高血尿素氮(OR=1.312,95%CI:1.007~1.710,P=0.045)、低白蛋白(OR=0.876,95%CI:0.794~0.967,P=0.009)是重症AP的独立危险因素。结论关注AP病因及早期监测血尿素氮和白蛋白水平有利于病情评估和临床治疗。Objective To investigate the clinical features of pediatric acute pancreatitis(AP)and risk factors of severe disease.Methods A total of 72 AP children who were admitted to Children’s Hospital affiliated to Zhengzhou University from January 2021 to June 2022 were included into this study.According to NASPGHAN guides for AP classification standards,they were divided into mild AP group(41 cases)and severe AP group(31 cases),severe AP group included moderate severe AP and severe AP.The general clinical data,laboratory test results,complications,treatment methods and other information of the patients were collected through medical record retrieval,and logistic regression was used to analyze the risk factors for severe AP.Results There were statistical differences in gender,etiological-composition ratio,C-reactive protein,serum albumin,serum urea nitrogen and serum Ca 2+between the mild group and severe group(P<0.05).High blood urea nitrogen(OR=1.312,95%CI:1.007-1.710,P=0.045)and low albumin(OR=0.876,95%CI:0.794-0.967,P=0.009)at admission were independent risk factors for moderate and severe AP.Conclusion Focusing on the etiology of AP and early monitoring of blood urea nitrogen and albumin levels are conducive to clinical treatment and disease assessment.

关 键 词：儿童 急性胰腺炎 重症 危险因素 

分 类 号：R657.5[医药卫生—外科学]