D-二聚体与纤维蛋白原比值在慢性阻塞性肺疾病急性加重期患者中的表达及临床意义  

The Expression and Clinical Significance of D-dimer to Fibrinogen Ratio in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：武晓敏[1] 李雷花[1] WU Xiaomin;LI Leihua(Department of Clinical Laboratory,Puyang People’s Hospital,Puyang 457100,China)

机构地区：[1]濮阳市人民医院检验科,河南濮阳457100

出　　处：《河南医学研究》2024年第8期1430-1433,共4页Henan Medical Research

摘　　要：目的探讨D-二聚体与纤维蛋白原比值(DFR)在慢性阻塞性肺疾病(COPD)急性加重期患者中的表达及临床意义。方法前瞻性纳入2021年2月至2023年2月医院收治的COPD急性加重期患者。根据患者28 d生存情况将其分为生存组和病死组。所有患者于入院时检测血清D-二聚体(D-D)、纤维蛋白原(Fib)水平,计算DFR。采用点二列相关性检验DFR与COPD急性加重期患者预后的关系,绘制受试者工作特征(ROC)曲线分析DFR对COPD急性加重期患者生存情况的预测价值。结果共纳入102例COPD急性加重期患者,其中18例病死,占比17.65%,纳入病死组,其余84例患者纳入生存组。病死组DFR高于生存组,差异有统计学意义(P<0.05)。经点二列相关性分析,DFR与COPD急性加重期患者病死呈正相关关系(r=0.431,P<0.001)。绘制ROC曲线,DFR对COPD急性加重期患者病死有一定预测价值(AUC=0.795,P<0.001)。结论COPD急性加重期病死患者DFR呈高表达,可作为COPD急性加重期患者生存情况的预测指标。Objective To investigate the expression and clinical significance of D-dimer to fibrinogen ratio(DFR)in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods Patients with acute exacerbation of COPD admitted to the hospital from February 2021 to February 2023 were then prospectively enrolled.They were divided into a survival group and a mortality group based on their 28 days survival.All patients were tested for serum D-dimer(D-D)and fibrinogen(Fib)levels at admission,and DFR was calculated.The relationship between DFR and the prognosis of patients with acute exacerbation of COPD was tested using a point two column correlation test,and the predictive value of DFR on the survival of patients with acute exacerbation of COPD was analyzed by drawing a receiver operating characteristic(ROC)curve.Results A total of 102 patients with acute exacerbation of COPD were included,of which 18 died,accounting for 17.65%.They were included in the mortality group,while the remaining 84 patients were included in the survival group.The DFR of the mortality group was higher than that of the survival group,and the difference was statistically significant(P<0.05).Through point two column correlation analysis,there was a positive correlation between DFR and mortality in patients with acute exacerbation of COPD(r=0.431,P<0.001).ROC curve was drawn,and DFR had certain predictive value for death in patients with acute exacerbation of COPD(AUC=0.795,P<0.001).Conclusion DFR is highly expressed in dead patients with acute exacerbations of COPD,which can be used as a predictor of survival in patients with acute exacerbations of COPD.

关 键 词：慢性阻塞性肺疾病 急性加重 D-二聚体 纤维蛋白原 

分 类 号：R446.1[医药卫生—诊断学]