血清IL-2、sST2表达与特发性膜性肾病免疫抑制剂治疗反应性的相关性  

Correlation Between Serum IL-2,sST2 Expression and Immunosuppressive Agent Response in Idiopathic Membranous Nephropathy

作　　者：王念华[1] 吴玉彩[1] WANG Nianhua;WU Yucai(Department of Nephrology,Puyang People’s Hospital,Puyang 457000,China)

机构地区：[1]濮阳市人民医院肾内科,河南濮阳457000

出　　处：《河南医学研究》2024年第8期1433-1436,共4页Henan Medical Research

摘　　要：目的探讨特发性膜性肾病患者血清白介素-2(IL-2)、可溶性生长刺激表达基因2蛋白(sST2)表达水平与免疫抑制剂治疗反应性的相关性。方法选取2020年1月至2022年10月于医院接受免疫抑制剂治疗的135例特发性膜性肾病患者,于入院时检测患者血清IL-2、sST2,并于治疗完成后测定24 h尿蛋白定量,依据患者治疗反应性分为缓解组与未缓解组。对比两组患者一般资料及入院时血清IL-2、sST2水平,采用点二列相关性分析血清IL-2、sST2水平与特发性膜性肾病免疫抑制剂治疗反应性的关系,并绘制受试者工作特征(ROC)曲线评估血清IL-2、sST2水平预测特发性膜性肾病免疫抑制剂治疗反应性的价值。结果135例特发性膜性肾病患者中共有132例完成规律治疗,经免疫抑制剂治疗6个月后,101例患者疾病缓解,纳入缓解组,其余31例患者纳入未缓解组。未缓解组年龄、入院时肾功能分级、疾病分期、血清IL-2、sST2水平均高于缓解组,差异有统计学意义(P<0.05);点二列相关性分析显示,血清IL-2、sST2水平与特发性膜性肾病免疫抑制剂治疗反应性不良风险呈正相关(r 1=0.428,P 1<0.001;r 2=0.344,P 2<0.001);绘制ROC曲线,结果显示,血清IL-2、sST2预测特发性膜性肾病免疫抑制剂治疗反应性不良的曲线下面积均>0.7,具有一定预测价值,且联合预测价值更高。结论血清IL-2、sST2表达水平与特发性膜性肾病患者免疫抑制剂治疗反应性密切相关,二者表达水平越高,治疗反应性越差,且联合检测可作为预测特发性膜性肾病患者免疫抑制剂治疗反应性的敏感指标。Objective To investigate the relationship between the levels of serum interleukin-2(IL-2),soluble growth stimulating expression gene 2 protein(sST2)and the responsiveness to immunosuppressive agent therapy in patients with idiopathic membranous nephropathy.Methods A total of 135 patients with idiopathic membranous nephropathy who received immunosuppressive agent treatment in hospital from January 2020 to October 2022 were selected.Serum IL-2 and sST2 were measured at admission,and 24 hours urine protein quantitation was measured after treatment.According to the treatment reactivity of patients,they were divided into remission group and non-remission group.The general information of the two groups of patients and the serum levels of IL-2 and sST2 at admission were compared,and the relationship between the serum levels of IL-2 and sST2 and the treatment responsiveness of idiopathic membranous nephropathy immunosuppressive agent was analyzed by point binary correlation.The receiver operating characteristic curve of the subjects was drawn to evaluate the value of serum IL-2 and sST2 levels in predicting the treatment responsiveness of idiopathic membranous nephropathy immunosuppressive agent.Results A total of 132 of 135 patients with idiopathic membranous nephropathy completed regular treatment.After 6 months of immunosuppressive agent treatment,101 patients were included in the remission group,and the rest 31 patients were included in the non-remission group.The age,renal function grading at admission,disease staging,serum IL-2,and sST2 levels in the non-remission group were all higher than those in the remission group,with statistical significant differences(P<0.05).Point binary correlation analysis showed that serum IL-2 and sST2 levels were positively correlated with the risk of adverse reaction to immunosuppressive agent treatment of idiopathic membranous nephropathy(r 1=0.428,P 1<0.001;r 2=0.344,P 2<0.001).The receiver operating characteristic was drawn,and the results showed that the area under the curve of s

关 键 词：特发性膜性肾病 免疫抑制剂 白介素-2 可溶性生长刺激表达基因2蛋白 治疗反应性 

分 类 号：R568.1[医药卫生—呼吸系统]