来曲唑辅助排卵诱导治疗与克罗米芬治疗多囊卵巢综合征的效果  

Effect of Letrozole Assisted Ovulation Induction Therapy and Clomiphene Citrate in the Treatment of Polycystic Ovary Syndrome

作　　者：刘慧源 孔琪 王慧 LIU Huiyuan;KONG Qi;WANG Hui(Reproductive Department,Zhumadian Central Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市中心医院生殖科,河南驻马店463000

出　　处：《河南医学研究》2024年第8期1480-1483,共4页Henan Medical Research

摘　　要：目的比较来曲唑辅助排卵诱导治疗与克罗米芬治疗多囊卵巢综合征(PCOS)的效果。方法选取2019年10月至2022年10月在驻马店市中心医院诊治的96例PCOS患者,按照随机数字表法分为两组,对照组48例和研究组48例,对照组接受克罗米芬辅助排卵诱导治疗,研究组在对照组基础上接受来曲唑辅助排卵诱导治疗,比较两组治疗前后的性激素水平、子宫内膜厚度、最大卵泡直径,以及促排卵、并发症及妊娠情况。结果治疗后,两组雌二醇(E 2)、黄体生成素(LH)、睾酮(T)和促卵泡素(FSH)较治疗前均升高,研究组E 2低于对照组(P<0.05),FSH、LH高于对照组(P<0.05),两组T水平差异无统计学意义(P>0.05)。与治疗前比较,两组治疗后子宫内膜厚度、最大卵泡直径增加(P<0.05),且与对照组比较,研究组治疗后子宫内膜厚度、最大卵泡直径增加(P<0.05)。研究组有卵泡、多卵泡数、临床妊娠、多胎妊娠、流产发生率与对照组比较,差异均无统计学意义(P>0.05)。研究组单卵泡数发生率高于对照组(P<0.05),泡未破裂黄素化综合征(LUF)、卵巢过度刺激综合征(OHSS)发生率低于对照组(P<0.05)。结论来曲唑辅助排卵诱导治疗在PCOS患者中具有较好的治疗效果,其能调节性激素水平,改善子宫内膜厚度和卵泡发育,增加卵泡发育,降低OHSS、LUF发生率。Objective To compare the effect of letrozole assisted ovulation induction therapy and clomiphene citrate in the treatment of polycystic ovary syndrome(PCOS).Methods A total of 96 PCOS patients who were treated in Zhumadian Central Hospital from October 2019 to October 2022 were selected.They were divided into two groups according to the random number table method,the control group(48 cases)and the research group(48 cases).The control group received clomiphene citrate assisted ovulation induction therapy,while the research group received letrozole assisted ovulation induction therapy on the basis of the control group.The levels of sex hormones,endometrial thickness,maximum follicle diameter,ovulation induction,complications and pregnancy were compared between the two groups before and after treatment.Results After treatment,the levels of estrogen(E 2),luteinizing hormone(LH),testosterone(T),follicle-stimulating hormone(FSH)in the two groups were all higher than before treatment,and the E 2 in the study group was lower than that in the control group(P<0.05),while the FSH and LH in the study group were higher than that in the control group(P<0.05),and the T levels in the two groups with no statistically difference(P>0.05).After treatment,the endometrial thickness and the maximum follicular diameter in both groups were higher than before treatment(P<0.05),and the study group was higher than the control group(P<0.05).Compared with the control group,the incidence of follicles,multiple follicles,clinical pregnancy,multiple pregnancies and abortion in the study group was not statistically significant(P>0.05).The incidence of single follicle in the study group was higher(P<0.05),and the incidence of bubble-like unruptured flavinization syndrome(LUF),ovarian hyperstimulation syndrome(OHSS)in the study group was lower(P<0.05).Conclusion Auxiliary ovulation induction therapy with letrozole has a better therapeutic effect in PCOS patients,which can regulate sex hormone levels,improve endometrial thickness and follicular devel

关 键 词：来曲唑 排卵诱导 克罗米芬 多囊卵巢综合症 效果 

分 类 号：R711.75[医药卫生—妇产科学]