维生素D在甲状腺功能减退患儿左旋甲状腺素钠片治疗期间辅助应用价值研究  

Study on the auxiliary application value of vitamin D during the treatment of levothyroxine sodium tablets in children with hypothyroidism

作　　者：付卫兰 钟丽雅 林美美 FU Wei-lan;ZHONG Li-ya;LIN Mei-mei(Neonatology Department,Huidong Women's and Children's Hospital,Huizhou 516300,China.)

机构地区：[1]惠东县妇幼保健院新生儿科,广东惠州516300

出　　处：《中国处方药》2024年第4期118-120,共3页Journal of China Prescription Drug

基　　金：惠州市科技计划项目(2022CZ010372)。

摘　　要：目的分析甲状腺功能减退患儿服用左旋甲状腺素钠片治疗时使用维生素D的效果。方法随机抽取某院2022年5月1日~2022年11月30期间收治的30例甲状腺功能减退患儿,利用随机数字表法将其分为对照组(左旋甲状腺素钠片)和研究组(左旋甲状腺素钠片+维生素D),各15例。对比两组应用效果。结果治疗后,研究组患者体重、身高均高于对照组,智力发育情况也较好,差异有统计学意义(P<0.05);治疗后,研究组TSH、TC、TG、LDL-C水平均低于对照组(P<0.05)。治疗后,研究组血钙含量明显高于对照组,差异有统计学意义(P<0.05)。结论甲状腺功能减退患儿服用左旋甲状腺素钠片治疗期间使用维生素D有助于调节总钙水平,防止骨代谢异常,促使疾病良好转归。Objective To analysis of the effect of using vitamin D when taking levothyroxine sodium tablets for treatment in children with hypothyroidism.Methods 30 children with hypothyroidism admitted to a hospital from May 1,2022 to November 30,2022 were randomly selected and divided into a control group(levothyroxine sodium tablets)and a study group(levothyroxine sodium tablets+vitamin D)using a random number table method,with 15 cases in each group.Compare the application effects between two groups.Results After treatment,the weight and height of the study group patients were higher than those of the control group,and their intellectual development was also better,with statistical significance(P<0.05).After treatment,the levels of TSH,TC,TG,and LDL-C in the study group were lower than those in the control group(P<0.05).After treatment,the blood calcium content in the study group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The use of vitamin D during the treatment of levothyroxine sodium tablets in children with hypothyroidism can help regulate total calcium levels,prevent abnormal bone metabolism,and promote good disease outcomes..

关 键 词：维生素D 左旋甲状腺素钠片 甲状腺功能减退 甲状腺功能三项 血脂水平 

分 类 号：R725.8[医药卫生—儿科]