二甲双胍联合针灸分期治疗肥胖型多囊卵巢综合征临床研究  

Clinical study of obese polycystic ovary syndrome treated by metformin combined with acupuncture stage treatment

作　　者：黄成怡 王春烨 HUANG Cheng-yi;WANG Chun-ye(Xiangshan Hospital of traditional Chinese medicine,Huangpu District,Shanghai 200020,China.)

机构地区：[1]上海市黄浦区香山中医医院,上海200020

出　　处：《中国处方药》2024年第4期162-168,共7页Journal of China Prescription Drug

基　　金：上海市黄浦区科研项目面上课题(HKM201918);上海市黄浦区卫生健康系统培育专科项目(2019PYZK07)。

摘　　要：目的探讨二甲双胍联合针灸分期治疗肥胖型多囊卵巢综合征临床疗效。方法选择肥胖型多囊卵巢综合征患者90例,随机分为研究组,对照组1,对照组2,每组各30例。研究组采用口服二甲双胍联合针灸分期治疗,根据月经周期不同阶段选择不同配穴;对照组1单纯口服二甲双胍治疗;对照组2在二甲双胍基础上联合固定穴位治疗,每组均连续治疗3个月经周期,观察临床症状和体征、实验室指标改善情况。结果研究组、对照组1和对照组2有效率分别为93.3%、60.0%和76.7%,差异具有统计学意义(P<0.001);针灸分期疗法和固定穴位疗法均能有效改善患者月经周期、体重指数(BMI)、腰臀比、体脂百分比(F%)、血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C),组间差异无统计学意义(P>0.05),但优于单纯二甲双胍疗法(P<0.05);在调节性激素方面,针灸分期疗法优于固定穴位疗法及单纯二甲双胍疗法;对于改善甘油三酯(TG)水平,三种疗法差异无统计学意义。研究组临床症状积分优于对照组1和对照组2。结论针灸分期疗法能够有效改善肥胖型多囊卵巢综合征月经周期、肥胖、多毛、痤疮等症、调节血脂及性激素水平,相对于其他疗法具有一定优势。Objective To investigate the clinical effect of metformin combined with acupuncture stage treatment of obese polycystic ovary syndrome(PCOS).Methods 90 obese patients with PCOS were randomly divided into the study group,the control group 1 and the control group 2,with 30 cases in each group.The study group was treated by oral metformin combined with acupuncture stage treatment,and different acupoints were selected according to different stages of the menstruation.The control group 1 was treated with oral metformin alone.The control group 2 was combined with fixed acupoints therapy and metformin.Each group was treated for three menstrual cycles,to observe the change of clinical symptoms,signs and laboratory indicators.Results The total effective rates of the study group,control group 1 and control group 2 were 93.3%,60.0%and 76.7%,and the difference between them was statistically significant(P<0.001).Both acupuncture stage treatment and fixed acupoints therapy could effectively improve the menstrual cycle,BMI,waist-to-hip ratio,F%,TC and LDL-C.There was no significant difference between these two methods(P>0.05),but they were better than metformin alone(P<0.05).As for regulating sex hormones,acupuncture stage treatment was better than fixed acupoints therapy and metformin alone.There was no difference on TG levels improving among these three treatments.The study group was better than both control groups in the clinical symptom.Conclusion Acupuncture stage treatment can effectively improve the menstrual cycle of PCOS,obesity,hairy,acne and other symptoms and signs,regulate blood lipid and sex hormone levels,has certain advantages compared with other therapies.

关 键 词：针灸分期疗法 多囊卵巢综合征 肥胖症 分期选穴 

分 类 号：R711.75[医药卫生—妇产科学]