微型介入式轴流血泵溶血和凝血模型研究进展分析  

Progress in the analysis of hemolysis and coagulation models for interventional micro-axial flow blood pumps

作　　者：王尚亭 付华林 路喆鑫(综述) 杨明(审校)[1] WANG Shangting;FU Hualin;LU Zhexin;YANG Ming(School of Electronic Information and Electrical Engineering,Shanghai Jiao Tong University,Shanghai 200240,P.R.China;Department of Cardiovascular Surgery,Shanghai General Hospital,Shanghai 201620,P.R.China)

机构地区：[1]上海交通大学电子信息与电气工程学院,上海200240 [2]上海市第一人民医院心外科,上海201620

出　　处：《生物医学工程学杂志》2024年第2期383-388,共6页Journal of Biomedical Engineering

基　　金：国家重点研发计划(2022YFC2402601)。

摘　　要：微型介入式轴流血泵作为心源性休克患者的有效治疗手段被广泛应用,而溶血和凝血问题往往是临床应用中重点关注的问题。本文针对微型轴流血泵溶血和凝血模型进行综述。首先介绍商用微型介入泵的结构特点和临床应用的相关问题,然后从溶血和凝血的基本机制出发,研究微型介入泵影响红细胞损伤和血小板活化的因素,重点回顾了目前关于溶血和凝血不同尺度模型(包括宏观、介观和微观)的进展。不同尺度模型对溶血和凝血研究的角度不同,因此在研究微型介入泵的溶血和凝血问题时,需要结合多尺度模型进行全面分析,以充分考虑介入泵复杂因素对溶血和凝血的影响。Interventional micro-axial flow blood pump is widely used as an effective treatment for patients with cardiogenic shock.Hemolysis and coagulation are vital concerns in the clinical application of interventional micro-axial flow pumps.This paper reviewed hemolysis and coagulation models for micro-axial flow blood pumps.Firstly,the structural characteristics of commercial interventional micro-axial flow blood pumps and issues related to clinical applications were introduced.Then the basic mechanisms of hemolysis and coagulation were used to study the factors affecting erythrocyte damage and platelet activation in interventional micro-axial flow blood pumps,focusing on the current models of hemolysis and coagulation on different scales(macroscopic,mesoscopic,and microscopic).Since models at different scales have different perspectives on the study of hemolysis and coagulation,a comprehensive analysis combined with multi-scale models is required to fully consider the influence of complex factors of interventional pumps on hemolysis and coagulation.

关 键 词：轴流血泵 溶血 凝血 多尺度模型 

分 类 号：R318[医药卫生—生物医学工程]