医用高分子微针在非透皮局部给药中的研究进展  

Research advances of biomedical polymeric microneedles for non-transdermal local drug delivery

作　　者：李海艳 韩宏娟 王璐 姚婧芝 肖文谦(综述) 李波(审校) LI Haiyan;HAN Hongjuan;WANG Lu;YAO Jingzhi;XIAO Wenqian;LI Bo(Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices,Chongqing University of Science and Technology,Chongqing 401331,R.R.China)

机构地区：[1]重庆科技大学、纳微复合材料与器件重庆市重点实验室,重庆401331

出　　处：《生物医学工程学杂志》2024年第2期406-412,420,共8页Journal of Biomedical Engineering

基　　金：重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0707,cstc2021jcyj-msxmX0360);重庆市教育委员会科学技术研究项目(KJQN202101534);重庆市研究生教育教学改革研究重点项目(yjg202036);国家级大学生创新创业训练计划项目(202311551004);重庆科技大学研究生科技创新计划项目(YKJCX2220209)。

摘　　要：微针是一种具有广阔发展前景的新型局部给药系统,因具有能够迅速穿透组织屏障、实现局部定点和靶向给药等优点,其应用也逐步扩展到非透皮的给药领域,可以为组织或器官的疾病或损伤提供快速、有效的治疗手段。经过文献检索发现医用高分子微针在非透皮给药的最新应用进展还缺乏归纳和总结,本文首先阐述了相关微针的制备材料及制造技术,接着对微针在非透皮给药领域中的典型应用进行了综述,主要涉及口腔、眼部、血管和心脏等组织或器官疾病的治疗及修复,最后总结现阶段微针在非透皮给药中存在的问题,对其发展进行了展望,以供相关领域的研究者借鉴与参考。Microneedles have emerged as the new class of local drug delivery system that has broad potential for development.Considering that the microneedles can penetrate tissue barriers quickly,and provide localized and targeted drug delivery,their applications have gradually expanded to non-transdermal drug delivery recently,which are capable of providing rapid and effective treatment for injuries and diseases of organs or tissues.However,a literature search revealed that there is a lack of summaries of the latest developments in non-transdermal drug delivery research by using biomedical polymeric microneedles.The review first described the materials and fabrication methods for the polymeric microneedles,and then reviewed a representative application of microneedles for non-transdermal drug delivery,with the primary focus being on treating and repairing the tissues or organs such as oral cavity,ocular tissues,blood vessels and heart.At the end of the article,the opportunities and challenges associated with microneedles for non-transdermal drug delivery were discussed,along with its future development,in order to provide reference for researchers in the relevant field.

关 键 词：微针 非透皮 药物递送 

分 类 号：TH77[机械工程—仪器科学与技术]