短效与长效硝苯地平治疗妊娠期高血压疾病的疗效对比  

Comparison of Short-Term and Long-Term Effects of Nifedipine in the Treatment of Gestational Hypertension

作　　者：王兰兰 王雪娟 WANG Lanlan;WANG Xuejuan(Department of Obstetrics,Rongcheng Maternal and Child Health Hospital,Rongcheng Shandong 264300,China;Department of Gynecology,Rongcheng Maternal and Child Health Hospital,Rongcheng Shandong 264300,China)

机构地区：[1]荣成市妇幼保健院产科,山东荣成264300 [2]荣成市妇幼保健院妇科,山东荣成264300

出　　处：《中国卫生标准管理》2024年第7期155-159,共5页China Health Standard Management

摘　　要：目的探讨妊娠期高血压疾病治疗中短效与长效硝苯地平的实际应用效果。方法选取2020年2月—2023年2月确诊且在荣成市妇幼保健院治疗的90例妊娠期高血压疾病患者,通过随机分组将患者分为观察组与对照组,各45例。对照组采取短效硝苯地平治疗,观察组采取硝苯地平控释片治疗,分析2组治疗后血压水平、治疗后24 h尿蛋白、血黏度、红细胞比容、分娩方式、母婴不良结局以及用药不良反应情况等。结果观察组治疗后舒张压、收缩压水平更低,差异有统计学意义(P<0.05)。观察组24 h尿蛋白水平、血黏度、红细胞比容小于对照组,差异有统计学意义(P<0.05)。观察组阴道分娩率(77.78%)高于对照组(44.44%),差异有统计学意义(P<0.05)。观察组妊娠期高血压疾病患者母婴不良结局发生率(6.66%)低于对照组(33.33%),差异有统计学意义(P<0.05)。观察组用药不良反应发生率(2.22%)低于对照组(15.56%),差异有统计学意义(P<0.05)。结论对妊娠期高血压疾病患者建议使用长效硝苯地平治疗,可更好地帮助患者控制血压,改善症状,预防不良妊娠结局。Objective To explore the practical effects of shortacting and long-acting nifedipine in the treatment of hypertension in pregnancy.Methods A total of 90 patients with gestational hypertension diagnosed from February 2020 to February 2023 and treated at Rongcheng Maternal and Child Health Hospital were selected for the study.The patients were randomly divided into an observation group and a control group,with 45 cases in each group.The control group was treated with short-term nifedipine,while the observation group was treated with nifedipine controlled-release tablets.The postoperative blood pressure,24-hour urine protein,blood viscosity,hematocrit,delivery method,adverse maternal and infant outcomes,and medication adverse reactions of two groups were analyzed.Results The observation group had lower levels of diastolic and systolic blood pressure after treatment,and the difference was statistically significant(P<0.05).The 24-hour urine protein level,blood viscosity,and hematocrit in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The vaginal delivery rate in the observation group(77.78%)was higher than that in the control group(44.44%),and the difference was statistically significant(P<0.05).The incidence of adverse maternal and infant outcomes in patients with gestational hypertension in the observation group(6.66%)was lower than that in the control group(33.33%),and the difference was statistically significant(P<0.05).The incidence of adverse drug reactions in the observation group(2.22%)was lower than that in the control group(15.56%),and the difference was statistically significant(P<0.05).Conclusion It is recommended to use long-acting nifedipine treatment for patients with hypertension during pregnancy.This method can help patients to better control blood pressure,improve symptoms and prevent adverse pregnancy outcomes.

关 键 词：妊娠期高血压疾病 硝苯地平 短效药 长效药 血压水平 作用机制 用药安全 

分 类 号：R854[医药卫生—航空、航天与航海医学]