吲哚布芬对行TKA患者术后静脉血栓形成情况及凝血机制的影响  

Effect of Indobufen on Venous Thromboembolism and Coagulation Mechanism in Patients Undergoing TKA

作　　者：王兴兰 傅方方 李光灿 WANG Xinglan;FU Fangfang;LI Guangcan(Pharmacy Department,Chongqing Kaizhou District People's Hospital,Chongqing 405400,China;不详)

机构地区：[1]重庆市开州区人民医院药剂科,重庆405400 [2]新余市人民医院呼吸内科,江西新余338000

出　　处：《中国医学创新》2024年第11期149-153,共5页Medical Innovation of China

摘　　要：目的:探讨吲哚布芬对行全膝关节置换术(TKA)患者术后静脉血栓形成(VTE)情况及凝血机制的影响。方法:选取2019年1月—2020年12月在重庆市开州区人民医院行单侧TKA的患者120例,随机分为两组,各60例。对照组术后给予阿司匹林口服,观察组术后给予吲哚布芬口服,两组均持续用药4周。比较两组患者术后VTE发生率、凝血指标[凝血酶原时间(prothrombin time,PT)、凝血酶时间(thrombin time,TT)、纤维蛋白原(fibrinogen,FIB)、D-二聚体(D-dimer,D-D)和血小板计数(platelet count,PLT)]及胃肠道不良反应发生率。结果:观察组术后VTE发生率为6.67%,低于对照组的18.33%(P<0.05)。治疗后,观察组PT、TT均长于对照组,FIB、D-D水平均低于对照组,PLT水平高于对照组,差异均有统计学意义(P<0.05)。观察组术后胃肠道不良反应发生率为3.33%,低于对照组的16.67%(P<0.05)。结论:吲哚布芬对行TKA患者具有良好的抗血小板聚集作用,可有效降低术后VTE的发生率,同时改善凝血机制,减少胃肠道不良反应,是一种安全有效的抗血栓药物。Objective:To investigate the effect of Indobufen on venous thromboembolism(VTE)and coagulation mechanism in patients undergoing total knee arthroplasty(TKA).Method:A total of 120 patients who underwent unilateral TKA from January 2019 to December 2020 in Chongqing Kaizhou District People's Hospital were randomly divided into two groups,60 cases in each group.The control group was given Aspirin orally after operation,and the observation group was given Indobufen orally after operation.Both groups continued medication for 4 weeks.The postoperative VTE incidence,coagulation indicators[prothrombin time(PT),thrombin time(TT),fibrinogen(FIB),D-dimer(D-D),and platelet count(PLT)]and gastrointestinal adverse reactions of the two groups were compared.Result:The incidence of VTE in the observation group was 6.67%,which was lower than 18.33% in the control group(P<0.05).After treatment,the PT and TT in the observation group were longer than those in the control group,the levels of FIB and D-D were lower than those in the control group,and the level of PLT was higher than that in the control group,with statistical significance(P<0.05).The incidence of postoperative gastrointestinal adverse reactions in the observation group was 3.33%,which was lower than 16.67% in the control group(P<0.05).Conclusion:Indobufen has a good antiplatelet aggregation effect on patients undergoing TKA,can effectively reduce the incidence of postoperative VTE,improve the coagulation mechanism,reduce gastrointestinal adverse reactions,and is a safe and effective antithrombotic drug.

关 键 词：吲哚布芬 全膝关节置换术 静脉血栓形成 凝血机制 

分 类 号：R687.4[医药卫生—骨科学]