瑞芬太尼复合七氟烷应用于剖宫产产妇的效果及对炎症细胞因子的影响  

Effect of Remifentanil Combined with Sevoflurane in Parturient Undergoing Cesarean Section and Its Influence on Inflammatory Cytokines

作　　者：陈玲利 程海涛[1] CHEN Lingli;CHENG Haitao(Department of Anesthesiology,Huangzhou District People's Hospital of Huanggang City,Huanggang 438000,China;不详)

机构地区：[1]黄冈市黄州区人民医院麻醉科,湖北黄冈438000

出　　处：《中国医学创新》2024年第12期10-13,共4页Medical Innovation of China

基　　金：湖北省卫生和计划生育委员会科研项目(WJ2017M244)。

摘　　要：目的:探讨瑞芬太尼复合七氟烷应用于剖宫产产妇的效果及对炎症细胞因子的影响。方法:选取98例2022年1—12月黄冈市黄州区人民医院收治的行剖宫产的产妇,随机分成试验组(n=49)、对照组(n=49)。对照组实施瑞芬太尼复合丙泊酚麻醉,试验组实施瑞芬太尼复合七氟烷麻醉。对比两组血流动力学、新生儿阿普加(Apgar)评分、不良反应和炎症细胞因子水平。结果:与麻醉前比较,两组切皮、术毕时平均动脉压和心率均升高,但试验组切皮、术毕时平均动脉压和心率均低于对照组,差异均有统计学意义(P<0.05)。试验组新生儿娩出1、5、10 min时的Apgar评分与对照组比较,差异均无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。术后1 d,两组各项炎症细胞因子水平均升高,但试验组超敏C反应蛋白、白介素-6和肿瘤坏死因子-α均低于对照组,差异均有统计学意义(P<0.05)。结论:瑞芬太尼复合七氟烷用于剖宫产产妇的效果显著,有助于维持其血流动力学,改善炎症细胞因子水平,对新生儿无明显影响,且不良反应较少。Objective:To explore the effect of Remifentanil combined with Sevoflurane in parturient underwent cesarean section and its influence on inflammatory cytokines.Method:A total of 90 parturients who underwent cesarean section in Huangzhou District People's Hospital of Huanggang City from January to December 2022 were randomly divided into experimental group(n=49)and control group(n=49).The control group was given Remifentanil combined with Propofol,and the experimental group was given Remifentanil combined with Sevoflurane.Hemodynamics,neonatal Apgar score,adverse reactions and inflammatory cytokine levels were compared between the two groups.Result:Compared with those before anesthesia,the mean arterial pressure and heart rate in both groups were increased at skin incision and the end of operation,but the mean arterial pressure and heart rate of the experimental group were lower than those of the control group,the differences were statistically significant(P<0.05).There were no significant differences in Apgar scores of newborns between experimental group and control group at 1,5 and 10 min after delivery(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).On the first day after operation,the levels of various in inflammatory cytokines in both groups were increased,but the levels of hypersensitive C reactive protein,interleukin-6 and tumor necrosis factor-αin experimental group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion:Remifentanil combined with Sevoflurane has a significant effect in parturient undergoing cesarean section,which helps to maintain the hemodynamics and improve the levels of inflammatory cytokines,and has no obvious effect on the newborn,and the adverse reaction is less.

关 键 词：瑞芬太尼 炎症细胞因子 剖宫产 七氟烷 不良反应 

分 类 号：R614[医药卫生—麻醉学]