湿毒膏联合亚甲蓝肛周封闭术对慢性肛周湿疹的治疗效果  

Therapeutic Effect of Shidu Ointment Combined with Perianal Closure with Methylthioninium Chloride on Chronic Perianal Eczema

作　　者：王莹 卢彦 李仙福 WANG Ying;LU Yan;LI Xianfu(Department of Dermatology,Ganzhou Hospital of Traditional Chinese Medicine,Ganzhou 341000,China;不详)

机构地区：[1]赣州市中医院皮肤科,江西赣州341000 [2]赣州市中医院肛肠科,江西赣州341000

出　　处：《中国医学创新》2024年第12期134-139,共6页Medical Innovation of China

摘　　要：目的:探究湿毒膏联合亚甲蓝肛周封闭术对慢性肛周湿疹患者肛周皮损、瘙痒及复发的影响。方法:选取2020年10月—2023年3月赣州市中医院诊治的慢性肛周湿疹患者80例,使用随机抽签法分对照组(n=40,给予亚甲蓝肛周封闭术治疗)及观察组(n=40,给予湿毒膏联合亚甲蓝肛周封闭术治疗)。评价对比两组临床疗效、肛周皮损及瘙痒程度、炎症因子、生活质量、复发率。结果:观察组、对照组总有效率分别为90.0%、72.5%,与对照组相比,观察组显著更高,差异有统计学意义(P<0.05);治疗4周后,两组湿疹面积及严重程度指数评分、视觉模拟评分法评分均明显下降,且与对照组[(3.79±1.18)、(3.32±0.94)分]比较,观察组[(2.61±0.79)、(2.72±0.75)分]均显著更低(P<0.05);治疗4周后,两组白介素(IL)-6及肿瘤坏死因子-α(TNF-α)水平均明显下降,IL-10水平均明显上升,且与对照组[(38.40±6.12)、(43.47±5.37)、(3.63±0.72)ng/L]比较,观察组IL-6、TNF-α[(29.39±5.24)、(32.17±5.12)ng/L]均显著更低,IL-10[(4.47±0.56)ng/L]显著更高(P<0.05);治疗2、4周后,两组皮肤病生活质量指数评分均明显下降,且与对照组[(10.08±2.05)、(7.35±1.16)分]比较,观察组[(8.34±1.44)、(5.21±0.92)分]均显著更低(P<0.05);观察组治愈患者中复发2例,复发率为18.18%,对照组治愈患者中复发2例,复发率为28.57%,两组复发率比较,差异无统计学意义(P>0.05)。结论:湿毒膏联合亚甲蓝肛周封闭术治疗慢性肛周湿疹,效果良好,可有效减轻肛周皮损、瘙痒程度及炎症反应,促进患处愈合,改善患者生活质量。Objective:To investigate the effect of Shidu Ointment combined with perianal closure with Methylthioninium Chloride on perianal lesion,pruritus and recrudescence in patients with chronic perianal eczema.Method:A total of 80 patients with chronic perianal eczema diagnosed and treated in Ganzhou Hospital of Traditional Chinese Medicine from October 2020 to March 2023 were selected and divided into control group(n=40,treated with perianal closure with Methylthioninium Chloride)and observation group(n=40,treated with Shidu Ointment combined with perianal closure with Methylthioninium Chloride)by random drawing method.The clinical efficacy,the degree of perianal lesion and pruritus,inflammatory factors,quality of life and recurrence rate were evaluated and compared between the two groups.Result:The total effective rate of observation group and control group was 90.0%and 72.5%,respectively,compared with the control group,that in the observation group was significantly higher,the difference was statistically significant(P<0.05).After 4 weeks of treatment,the eczema area and severity index scores and visual analogue scale scores of both groups decreased significantly,compared with the scores of the control group[(3.79±1.18),(3.32±0.94)scores],the scores of the observation group[(2.61±0.79),(2.72±0.75)scores]were significantly lower(P<0.05).After 4 weeks of treatment,the levels of interleukin(IL)-6 and tumor necrosis factor-α(TNF-α)in both groups decreased significantly,and IL-10 levels increased significantly,compared with the control group[(38.40±6.12),(43.47±5.37)and(3.63±0.72)ng/L],the levels of IL-6 and TNF-α[(29.39±5.24),(32.17±5.12)ng/L]in the observation group were significantly lower,and the level of IL-10[(4.47±0.56)ng/L]in the observation group was significantly higher(P<0.05).After 2 and 4 weeks of treatment,the dermatology life quality index scores in both groups decreased significantly,and the scores of the observation group[(8.34±1.44),(5.21±0.92)scores]were significantly lower than(10.08±2.

关 键 词：湿毒膏 亚甲蓝 肛周封闭术 慢性肛周湿疹 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]