LISA技术与INSURE技术治疗早产儿呼吸窘迫综合征的效果比较  

Comparison of the Effect of LISA Technique and INSURE Technique in the Treatment of Respiratory Distress Syndrome of Preterm Infants

作　　者：刘祥英[1] 何帆 吴金星[3] 魏文超 晏长红[1] 王巧芳[2] 吴丹 刘春子 LIU Xiangying;HE Fan;WU Jinxing;WEI Wenchao;YAN Changhong;WANG Qiaofang;WU Dan;LIU Chunzi(Department of Neonatology,Jiangxi Provincial Children's Hospital,Nanchang 330038,China;不详)

机构地区：[1]江西省儿童医院新生儿科,江西南昌330038 [2]江西省儿童医院新生儿重症监护室,江西南昌330038 [3]江西省儿童医院信息管理科,江西南昌330038

出　　处：《中国医学创新》2024年第12期144-148,共5页Medical Innovation of China

基　　金：江西省卫生健康委员会科技计划项目(20203660)。

摘　　要：目的:探讨微创注入肺表面活性物质(less invasive surfactant administration,LISA)与气管插管-肺表面活性物质-拔管(intubation-surfactant-extubate,INSURE)两种不同给药方法在早产儿呼吸窘迫综合征(respiratory distress syndrome,RDS)中的应用效果。方法:选取2019年1月1日—2022年8月31日江西省儿童医院收治的55例NRDS患儿,运用随机数字表法,分为LISA组(给予LISA技术,n=29)和INSURE组(给予INSURE技术,n=26)。比较两组治疗相关指标、并发症发生情况。结果:两组二次牛肺表面活性剂(CPS)使用率比较,差异无统计学意义(P>0.05);LISA组72 h内有创机械通气治疗率低于INSURE组,机械通气时间、总用氧时间及住院时间均短于INSURE组,差异均有统计学意义(P<0.05)。LISA组支气管肺发育不良(BPD)和早产儿视网膜病变(ROP)发生率均低于INSUR组,差异均有统计学意义(P<0.05),但两组其他并发症发生率比较,差异均无统计学意义(P>0.05)。结论:与INSURE技术相比,LISA技术治疗早产儿RDS,能有效降低有创机械通气率,缩短用氧时间,并减少BPD及ROP的发生。Objective:To discuss the application effect of two different administration methods of less invasive surfactant administration(LISA)and intubation-surfactant-extubate(INSURE)on respiratory distress syndrome(RDS)in preterm infants.Method:A total of 55 children with NRDS treated in Jiangxi Provincial Children's Hospital from January 1,2019 to August 31,2022 were divided into LISA group(given LISA technique,n=29)and INSURE group(given INSURE technique,n=26)by random number table method.Treatment related indexes and complications were compared between the two groups.Result:There was no significant difference in the utilization rate of secondary Calf Pulmonary Surfactant(CPS)between the two groups(P>0.05).The treatment rate of invasive mechanical ventilation within 72 h in LISA group was lower than that in INSURE group,and the mechanical ventilation time,total oxygen use time and hospital stay were shorter than those in INSURE group,the differences were statistically significant(P<0.05).The incidences of broncho-pulmonary dysplasia(BPD)and retinopathy of prematurity(ROP)in LISA group were lower than those in INSUR group,the differences were statistically significant(P<0.05),but there were no significant differences in the incidences of other complications between the two groups(P>0.05).Conclusion:Compared with INSURE technique,LISA technique can effectively reduce the mechanical ventilation rate,shorten the oxygen use time,and reduce the occurrence of BPD and ROP in the treatment of RDS in preterm infants.

关 键 词：早产儿 呼吸窘迫综合征 微创注入肺表面活性物质 气管插管-肺表面活性物质-拔管 

分 类 号：R722.6[医药卫生—儿科]