运动改善创伤性脑外伤的研究进展  

New insights into Exercise-Induced Amelioration of Traumatic Brain Injury

作　　者：隆远水 徐子博 刘素娟 LONG Yuan-Shui;XU Zi-Bo;LIU Su-Juan(School of Basic Medical Sciences,Tianjin Medical University,Tianjin 300070,China;Second Clinical Medical College,Tianjin Medical University,Tianjin 300211,China;Department of Anatomy and Histology,School of Basic Medical Sciences,Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津医科大学基础医学院,天津300070 [2]天津医科大学第二临床医学院,天津300211 [3]天津医科大学基础医学院人体解剖与组织胚胎学系,天津300070

出　　处：《生理科学进展》2024年第2期99-106,共8页Progress in Physiological Sciences

基　　金：中国博士后科学基金第66批面上项目(2019M661042)资助课题。

摘　　要：创伤性脑外伤(traumatic brain injury,TBI)是由外力作用引起的脑功能改变或其他脑部病理学变化,是世界范围内的重大公共卫生问题。目前大量研究证明运动作为非药物治疗方式可有效改善TBI。损伤前后的运动均可通过相关机制有益于TBI患者的康复。本文综述了创伤前/后运动对TBI的影响及其潜在调控机制,以期为深入理解运动改善TBI的研究机制及运动疗法在TBI临床中的应用提供理论依据。Traumatic brain injury(TBI)is defined as functional alterations or other pathological changes in the brain caused by external forces,which is a significant public health issue worldwide.Currently,a large number of studies have proved that exercise,as a nonpharmacological treatment,can effectively improve TBI.Exercise both before and after injury can benefit TBI recovery through specific mechanisms.This article summarizes the effects of exercise before and after injury on TBI and their potential regulatory mechanisms,aiming to provide an in-depth understanding of the mechanisms through which exercise improves TBI,thereby offering a theoretical basis for the clinical application of exercise in the prevention and treatment of TBI.

关 键 词：创伤性脑外伤 运动 氧化应激 炎症反应 脑源性神经营养因子 

分 类 号：R339.4[医药卫生—人体生理学] R493[医药卫生—基础医学]