巨噬细胞上髓系细胞触发受体-1/2在炎症性肠病中的作用研究进展  

Research Progress on the Roles of TREM-1/2 on Macrophages in Inflammatory Bowel Disease

作　　者：周子鸣 张咏梅 ZHOU Zi-Ming;ZHANG Yong-Mei(Jiangsu Province Key Laboratory of Anesthesiology,Xuzhou Medical University,Xuzhou 221004,China;Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology,Xuzhou Medical University,Xuzhou 221004,China;NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs,Xuzhou Medical University,Xuzhou 221004,China)

机构地区：[1]徐州医科大学江苏省麻醉学重点实验室,徐州221004 [2]徐州医科大学江苏省麻醉与镇痛应用技术重点实验室,徐州221004 [3]徐州医科大学国家药品监督管理局麻醉精神药物研究与评价重点实验室,徐州221004

出　　处：《生理科学进展》2024年第2期116-125,共10页Progress in Physiological Sciences

基　　金：科技创新2030-“脑科学与类脑研究”重大项目(2021ZD0203100);国家自然科学基金(82271257,82071228);江苏省研究生科研创新计划(KYCX23_2957)资助课题。

摘　　要：炎症性肠病(inflammatory bowel disease,IBD)是以克罗恩病(Crohn’s disease,CD)和溃疡性结肠炎(ulcerative colitis,UC)为代表的慢性肠道炎症性疾病,机制涉及遗传易感性以及环境与微生物群间相互作用削弱肠道屏障导致免疫激活等多种途径。近年来,巨噬细胞上表达的TREMs(triggering receptors expressed on myeloid cells),即髓系细胞触发受体,被发现在固有免疫和适应性免疫中发挥重要作用,并与IBD的发生发展密切相关。本文将着重对TREM-1/2(TREM-1和TREM-2)的结构、配体和作用,其在巨噬细胞上参与IBD与伴发精神障碍的机制研究进行概述,旨在为IBD的预防和治疗提供理论支持。Inflammatory bowel disease(IBD)is a chronic intestinal inflammatory disease represented by Crohn's disease(CD)and ulcerative colitis(UC).Mechanisms underlying its onset and development involve genetic susceptibility,as well as multiple pathways such as the environmental and microbial interactions that weaken the intestinal barrier and lead to immune activation.Recent research has indicated that triggering receptors expressed on myeloid cells(TREMs)expressed on macrophages play critical roles in both innate and adaptive immune responses,closely associated with the occurrence and development of IBD.This article reviews the structures,ligands,and functions of TREM-1/2(TREM-1 and TREM-2),as well as mechanisms underlying the involvement of TREM-1/2 in IBD and the accompanying mental disorders,aiming to provide theoretical support for the prevention and treatment of IBD.

关 键 词：炎症性肠病 巨噬细胞 TREM-1 TREM-2 

分 类 号：R392[医药卫生—免疫学]