机械敏感性离子通道Piezo1的生理作用  

Physiological Roles of the Mechanosensitive Channel Piezo1

作　　者：刘鲁冰 刘雪环 李媛 LIU Lu-Bing;LIU Xue-Huan;LI Yuan(Experimental Center,Shandong University of Traditional Chinese Medicine;Key Laboratory of Traditional Chinese Medicine Classical Theory,Ministry of Education;Shandong Provincial Key Laboratory of Traditional Chinese Medicine for Basic Research,Jinan 250355,China)

机构地区：[1]山东中医药大学实验中心 [2]中医药经典理论教育部重点实验室 [3]中医药基础研究山东省重点实验室,济南250355

出　　处：《生理科学进展》2024年第2期155-162,共8页Progress in Physiological Sciences

基　　金：山东省自然科学基金青年项目(ZR2023QH051)资助课题。

摘　　要：组织或细胞受到外界机械力刺激后会产生机械转导,从而引起一系列的信号调控过程,而机械敏感性离子通道是实现信号转导过程的主力军。研究较为广泛的是机械敏感性通道Piezo1。Piezo1已在多种哺乳动物组织中被发现,能够在接受机械刺激后影响多个信号通路,涉及血管扩张、细胞迁移与炎症反应等,为了发掘Piezo1的潜在治疗价值,提高对其功能的认识,本文检索了关于Piezo1的文献报道,总结了Piezo1在心血管系统、运动系统、神经系统、呼吸系统、消化系统、生殖系统中的最新研究进展。Mechanotransduction occurs when tissues or cells are stimulated by external mechanical forces,initiating a series of signaling processes,with mechanosensitive ion channels playing a pivotal role in this signaling cascade.Among these channels,Piezo1 has been widely studied.Piezo1 has been found in a variety of mammalian tissues and can affect multiple signaling pathways after mechanical stimulation,involving processes such as vasodilation,cell migration,and inflammatory response.To explore the potential therapeutic value of Piezo1 and improve the understanding of its function,this article reviews literature on Piezo1 and summarizes the latest research progress on Piezo1 in the cardiovascular system,locomotor system,nervous system,respiratory system,digestive system,and reproductive system.

关 键 词：Piezo1 内皮功能障碍 骨细胞凋亡 阿尔茨海默病 细胞迁移 

分 类 号：R331[医药卫生—人体生理学]