基于中医“肾-脑-骨”轴探讨女贞子及其活性成分的多脏器药理作用及潜在调控机制  

Exploration of multi-organ pharmacological effects and underlying regulatory mechanisms of Ligustri Lucidi Fructus and its active components based on the"kidney-brain-bone"axis in traditional Chinese medicine

作　　者：张佳莉 张岩[1,2] ZHANG Jiali;ZHANG Yan(Institute of Spinal Diseases,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Key Laboratory of Muscle and Bone Theories and Therapies,Ministry of Education,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院脊柱病研究所,上海200032 [2]教育部筋骨理论与治法重点实验室,上海200032

出　　处：《上海中医药杂志》2024年第5期1-8,共8页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家重点研发计划中医药现代化重点专项(2023YFC3504305);国家自然科学基金项目(82074468);上海市科委科技创新行动计划项目(21400760400)。

摘　　要：女贞子作为一种传统的补益肝肾中药,在中医药临床应用中具有重要地位。随着现代科技的发展,对女贞子的药理学活性研究也日益深入。“肾-脑-骨”轴的概念源于“肾主骨,生髓,通于脑”的中医理论,女贞子的多脏器药理学活性与该理论内涵具有紧密的契合点。基于“肾-脑-骨”轴的理论基础,旨在探讨女贞子及其活性成分的多脏器药理学作用及潜在调控机制,以期为临床应用与药物开发提供理论依据。NuZhenzi(Ligustri Lucidi Fructus),a traditional Chinese medicinal herb known for its liver and kidney nourishing properties,holds a significant position in the clinical application of traditional Chinese medicine(TCM).With the advancement of modern science and technology,pharmacological research on Ligustri Lucidi Fructus has become increasingly comprehensive.The concept of the kidney-brain-bone axis is derived from the TCM theory that the kidney governs the bones,generates marrow,and connects to the brain,which closely aligns with the multi-organ pharmacological activities of Ligustri Lucidi Fructus.Based on the theoretical foundation of the kidney-brain-bone axis,this article aims to explore the multi-organ pharmacological effects and potential regulatory mechanisms of Ligustri Lucidi Fructus and its active components,in hopes of providing a theoretical basis for clinical application and drug development.

关 键 词：女贞子 “肾-脑-骨”轴 中药研究 活性成分 药理作用 调控机制 

分 类 号：R285[医药卫生—中药学]