维生素C联合果糖二磷酸钠治疗新生儿窒息后心肌损伤的效果  

Effect of Vitamin C combined with Fructose Diphosphate Sodium in the treatment of myocardial injury after neonatal asphyxia

作　　者：周慧娟 ZHOU Huijuan(Department of Neonatology,Yangxin People’s Hospital,Hubei Province,Yangxin 435200,China)

机构地区：[1]湖北省阳新县人民医院新生儿科,湖北阳新435200

出　　处：《妇儿健康导刊》2024年第8期53-56,共4页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的探讨维生素C联合果糖二磷酸钠治疗新生儿窒息后心肌损伤的效果。方法选取2020年3月至2023年3月阳新县人民医院新生儿科收治的80例窒息后心肌损伤新生儿作为研究对象,按照随机数字表法分为两组,每组各40例。参照组给予对症治疗及维生素C,治疗组在参照组基础上给予果糖二磷酸钠,比较两组治疗效果。结果治疗组治疗优良率高于参照组,差异有统计学意义(P<0.05);治疗后,治疗组肌酸激酶、肌酸激酶同工酶、α-羟丁酸脱氢酶、丙二醛、晚期氧化蛋白产物水平低于参照组,超氧化物歧化酶水平高于参照组,差异有统计学意义(P<0.05);治疗组症状缓解时间、住院时间均短于参照组,差异有统计学意义(P<0.05)。结论维生素C联合果糖二磷酸钠治疗新生儿窒息后心肌损伤的效果显著,能够改善心肌代谢,减轻心肌损伤,促进症状缓解,值得推广。Objective To explore the effect of Vitamin C combined with Fructose Diphosphate Sodium in the treatment of myocardial injury after neonatal asphyxia.Methods A total of 80 newborns with myocardial injury after asphyxia admitted to Department of Neonatology,Yangxin People’s Hospital from March 2020 to March 2023 were selected and divided into two groups by the random number table method,with 40 cases in each group.The reference group was given symptomatic treatment and Vitamin C,while the treatment group was given Fructose Diphosphate Sodium on the basis of the reference group.The treatment effect of the two groups was compared.Results The excellent and good rate of treatment in the treatment group was higher than that in the reference group,the difference was statistically significant(P<0.05).After treatment,the levels of creatine kinase,creatine kinase muscle and brain isoenzyme,α-hydroxybutyrate dehydrogenase,malondialdehyde and advanced oxidation protein products in the treatment group were lower than those in the reference group,the level of superoxide dismutase in the treatment group was higher than that in the reference group,the differences were statistically significant(P<0.05).The symptom relief time and the length of hospitalization in the treatment group were shorter than those in the reference group(P<0.05).Conclusion Vitamin C combined with Fructose Diphosphate Sodium treating myocardial injury after neonatal as phyxia has significant effect,which can improve myocardial metabolism,reduce myocardial injury,promote the alleviation of symptoms,and is worthy of promotion.

关 键 词：维生素C 果糖二磷酸钠 新生儿窒息 心肌损伤 

分 类 号：R722.12[医药卫生—儿科]