生物水凝胶激光加工工艺及体外生物相容性研究  

Study on Laser Processing Technology of Biohydrogel and Its Biocompatibility in Vitro

作　　者：钱俊[1,2] 贺永[1] 徐丹泓 张俊杰 QIAN Jun;HE Yong;XU Danhong;ZHANG Junjie(College of Mechanical Engineering,Zhejiang University,Hangzhou 310058,China;Engineering Training Center,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]浙江大学机械工程学院,浙江杭州310058 [2]浙江大学工程训练中心,浙江杭州310058

出　　处：《电加工与模具》2024年第2期43-47,共5页Electromachining & Mould

基　　金：国家自然科学基金项目(52235007)。

摘　　要：针对生物水凝胶增材制造无法实现精细结构打印的问题,采用激光加工对SA水凝胶和GelMA水凝胶进行实验,通过激光切割、激光雕刻等探究了激光加工生物水凝胶的机制及各参数对激光加工效果的影响,通过细胞增殖实验分析HUVECs细胞在激光加工的水凝胶上的生长情况。实验表明,激光功率、进给速度等参数对于激光加工水凝胶的深度和表面质量有较大影响,细胞能够在激光加工的水凝胶上正常增殖,这可为生物医学相关应用提供有益的指导。In order to solve the problem that the production of biohydrogel additives cannot achieve fine structure printing,the laser processing was used to experiment SAhydrogel and GelMA hydrogel.The mechanism of laser processing biohydrogel and the influence of parameters on the laser processing effect were explored through laser cutting,laser engraving and other experiments,and the growth of HUVECs cells on the laser processed hydrogel was analyzed through cell proliferation experiments.The experiment showed that the parameters such as laser power and feed speed have great impacts on the depth and surface quality of laser processed hydrogels,and HUVECs cells can proliferate normally on the processed hydrogels,whichprovides a useful guidance for biomedical applications.

关 键 词：生物水凝胶 激光加工 生物相容性 细胞增殖 

分 类 号：TG665[金属学及工艺—金属切削加工及机床]