膳食大蒜摄入与早产风险的相关性研究  

Dietary garlic intake and risk of preterm birth

作　　者：王芳 姚婷婷[2] 许茸茸 刘青[1] WANG Fang;YAO Tingting;XU Rongrong;LIU Qing(Gynecology with integrated traditional and western medicine,Gansu Provincial Maternity and Child Care Hospital,Lanzhou,Gansu,China,730050)

机构地区：[1]甘肃省妇幼保健院中西医结合妇科,兰州730050 [2]甘肃省妇幼保健院生殖内分泌科 [3]甘肃省妇幼保健院产一科

出　　处：《中国生育健康杂志》2024年第3期213-218,共6页Chinese Journal of Reproductive Health

基　　金：甘肃省卫生行业科研计划项目(GSWSKY2020-36)。

摘　　要：目的 探析膳食大蒜摄入与早产风险之间的相关性。方法 2010—2012年甘肃省妇幼保健院出生队列研究,共纳入9 710例符合纳入标准的孕妇,调查一般人口学特征、围孕期大蒜摄入情况及其胎儿分娩时的信息。使用多因素Logistic回归模型来分析膳食中大蒜摄入与早产的关系。结果 生蒜的摄入可降低早产风险,且具有剂量依赖性(总体:OR=0.81,95%CI:0.69~0.96;孕前:OR=0.81,95%CI:0.68~0.95;<2次/周:OR=0.81,95%CI:0.69~0.97,≥2次/周:OR=0.79,95%CI:0.64~0.97;P_(trend)=0.03;孕期:OR=0.82,95%CI:0.70~0.96;<2次/周:OR=0.83,95%CI:0.71~0.98,≥2次/周:OR=0.79,95%CI:0.65~0.97;P_(trend)=0.03),尤其是与非胎膜早破型早产呈显著负相关(总体:OR=0.67,95%CI:0.53~0.85;孕前:OR=0.69,95%CI:0.55~0.88;孕期:OR=0.68,95%CI:0.55~0.85),而与医源性早产和胎膜早破型早产无显著关联。结论 膳食生蒜摄入可降低早产风险,尤其是非胎膜早破型早产,且呈明显剂量依赖性。Objective To analyze the association between dietary garlic intake and risk of preterm birth.Methods A birth cohort study was conducted in 2010-2012 at Gansu Provincial Maternity&Child Care Hospital in Lanzhou,China.A total of 9,710 pregnant women were enrolled.The general demography characteristics,garlic intake in the perinatal period and the information of fetal delivery were investigated.A multivariate logistic regression models was used to analyze the relationship between dietary garlic intake and preterm birth.Results Raw garlic intake reduced the risk of preterm birth with a dose-response relationship(overall:OR=0.81,95%CI:0.69-0.96;before pregnancy:OR=0.81,95%CI:0.68-0.95;<2 times/week:OR=0.81,95%CI:0.69-0.97,≥2 times/week:OR=0.79,95%CI:0.64-0.97;P_(trend)=0.03;during pregnancy:OR=0.82,95%CI:0.70-0.96;<2 times/week:OR=0.83,95%CI:0.71-0.98,≥2 times/week:OR=0.79,95%CI:0.65-0.97;P_(trend)=0.03).Especially there was a significant negative correlation with spontaneous preterm without premature rupture of membranes(overall:OR=0.67,95%CI:053-0.85;before pregnancy:OR=0.69,95%CI:0.55-0.88;during pregnancy:OR=0.68,95%CI:0.55-0.85).However,there was no significant association with iatrogenic preterm birth and premature rupture of membranes.Conclusion Dietary raw garlic intake can reduce the risk of preterm birth with dose-response relationship,especially spontaneous preterm without premature rupture of membranes.

关 键 词：早产 大蒜 膳食营养 出生队列研究 

分 类 号：R17[医药卫生—妇幼卫生保健] R71[医药卫生—公共卫生与预防医学]