不同抗生素配伍布地奈德方案治疗小儿社区获得性肺炎的效果  

Effect of Different Antibiotics Combined with Budesonide in the Treatment of Community Acquired Pneumonia in Children

作　　者：赵彩艳 刘冬 ZHAO Caiyan;LIU Dong(Department of Pediatrics,Ninghe District Hospital,Tianjin 301500,China)

机构地区：[1]天津市宁河区医院儿科,天津301500

出　　处：《中国药物滥用防治杂志》2024年第3期488-492,共5页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨不同抗生素配伍布地奈德对小儿社区获得性肺炎的治疗效果及对炎症因子水平的影响。方法:选取本院2020年2月—2023年2月收治的86例社区获得性肺炎患儿,应用随机数字表法分为三组。对照组采取阿奇霉素+布地奈德治疗,观察A组采取阿奇霉素+头孢噻肟钠+布地奈德治疗,观察B组采取阿奇霉素+拉氧头孢钠+布地奈德治疗,比较三组临床疗效、症状消失时间、炎症因子表达水平[白细胞计数(WBC)、白细胞介素-6(IL-6)、降钙素原(PCT)、C反应蛋白(CRP)]。结果:观察B组和观察A组治疗总有效率高于对照组,且观察B组高于观察A组(P<0.05);观察B组和观察A组患儿肺部啰音/喘鸣音消失时间、咳嗽消失时间、发热总天数、影像学恢复时间短于对照组,且观察B组短于观察A组(P<0.05);三组治疗后WBC、IL-6、PCT、CRP水平低于治疗前,且观察A组和观察B组低于对照组,观察B组低于观察A组(P<0.05)。结论:二联抗菌药物联合布地奈德对小儿社区获得性肺炎的治疗效果显著,且采取阿奇霉素+拉氧头孢钠可进一步改善小儿社区获得性肺炎的临床疗效,缩短症状持续时间,降低炎症因子水平。Objective:To investigate the therapeutic effect of different antibiotics combined with budesonide on communityacquired pneumonia in children and its effect on the level of inflammatory factors.Methods:A total of 86 children with communityacquired pneumonia admitted to our hospital from February 2020 to February 2023 were selected and divided into three groups by random number table method.The control group was treated with azithromycin+budesonide,the observation group A was treated with azithromycin+cefotaxime sodium+budesonide,and the observation group B was treated with azithromycin+latamoxef sodium+budesonide.The clinical efficacy,symptom disappearance time,and expression levels of inflammatory factors[white blood cell count(WBC),interleukin-6(IL-6),procalcitonin(PCT),C-reactive protein(CRP)]were compared among the three groups.Results:The total effective rate of observation group B and observation group A was higher than that of control group,and that of observation group B was higher than that of observation group A(P<0.05).The disappearance time of pulmonary rales/wheezing,cough,fever and imaging recovery time in the observation group B and the observation group A were shorter than those in the control group,and those in the observation group B were shorter than those in the observation group A(P<0.05).The levels of WBC,IL-6,PCT and CRP in the three groups after treatment were lower than those before treatment,and those in the observation group A and the observation group B were lower than the control group,and those in the observation group B were lower than those in the observation group A(P<0.05).Conclusion:The therapeutic effect of dual antibacterial drugs combined with budesonide on community-acquired pneumonia in children is significant,and azithromycin+latamoxef sodium can further improve the clinical eficacy of community-acquired pneumonia in children,shorten the duration of symptoms,and reduce the level of inflammatory factors.

关 键 词：布地奈德 阿奇霉素 头孢噻肟钠 拉氧头孢钠 社区获得性肺炎 炎症因子 

分 类 号：R725.6[医药卫生—儿科]