替格瑞洛联合抗栓胶囊治疗急性心肌梗死的效果观察  

Observation on the Effect of Ticagrelor Combined with Antithrombotic Capsule in the Treatment of Acute Myocardial Infarction

作　　者：丁磊 刘岩 谭效锋[3] DING Lei;LIU Yan;TAN Xiaofeng(Department of Pharmacy,Gujiasi Street Community Health Service Center,Hexi District,Tianjin 300210,China;International Diagnosis and Treatment Center,Tianjin Hospital,Tianjin 300299,China;Department of General Medicine,Tianjin Hospital,Tianjin 300299,China)

机构地区：[1]天津市河西区挂甲寺街社区卫生服务中心药剂科,天津300210 [2]天津市天津医院国际诊疗中心,天津300299 [3]天津市天津医院普内科,天津300299

出　　处：《中国药物滥用防治杂志》2024年第3期508-511,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:研究替格瑞洛联合抗栓胶囊治疗急性心肌梗死的效果。方法:选择2020年1月—2022年12月本院收治的80例急性心肌梗死患者,随机分为对照组和观察组,每组40例。对照组服用替格瑞洛,观察组联用抗栓胶囊。比较两组血液流变学指标(全血还原黏度、血栓形成系数、全血黏度、凝血因子Ⅰ和血浆黏度)、中医症状评分、血清超氧化物歧化酶(SOD)、髓过氧化物酶(MPO)、丙二醛(MDA)和可溶性致癌抑制因子2(sST2)水平。结果:观察组全血还原黏度、血栓形成系数、全血黏度、凝血因子Ⅰ和血浆黏度低于对照组(P<0.05);观察组心悸、胸闷、眩晕、痰多气短和神疲乏力评分低于对照组(P<0.05);观察组血清MPO、MDA和s ST2水平低于对照组,SOD水平高于对照组(P<0.05)。结论:替格瑞洛联合抗栓胶囊对急性心肌梗死有显著的效果,能明显改善血液流变学,减轻症状,有效改善氧化应激状态。Objective:To study the effect of ticagrelor combined with antithrombotic capsule in the treatment of acute myocardial infarction.Methods:A total of 80 patients with acute myocardial infarction admitted to our hospital from January 2020 to December 2022 were randomly divided into control group and observation group,with 40 patients in each group.The control group was treated with ticagrelor,and the observation group was treated with antithrombotic capsules.The hemorheological indexes(whole blood reduced viscosity,thrombosis coefficient,whole blood viscosity,coagulation factor I and plasma viscosity),TCM symptom score,serum superoxide dismutase(SOD),myeloperoxidase(MPO),malondialdehyde(MDA)and soluble carcinogenic inhibitor 2(sST2)levels were compared between the two groups.Results:The whole blood reduced viscosity,thrombosis coefficient,whole blood viscosity,coagulation factor I and plasma viscosity in the observation group were lower than those in the control group(P<0.05).The scores of palpitation,chest tightness,vertigo,phlegm and shortness of breath and mental fatigue in the observation group were lower than those in the control group(P<0.05).The levels of serum MPO,MDA and sST2 in the observation group were lower than those in the control group,and the level of SOD was higher than that in the control group(P<0.05).Conclusion:Ticagrelor combined with antithrombotic capsule has a significant effect on acute myocardial infarction,which can significantly improve hemorheology,relieve symptoms and effectively improve oxidative stress.

关 键 词：替格瑞洛 抗栓胶囊 急性心肌梗死 

分 类 号：R542.22[医药卫生—心血管疾病]