基于数据挖掘技术对《三因极一病证方论》中治疗头痛方剂的用药规律研究  

A study on the rule of medication of prescriptions on headache in Sanyin Ji Yi Bingzheng Fang Lun based on data mining technology

作　　者：李嘉慧 张斌霞[2] 常光灿 李昕玥 韩一恒 王煊 戴晨璐 LI Jiahui

机构地区：[1]南京中医药大学,江苏南京210023 [2]南京中医药大学附属常州市中医医院,江苏常州213000

出　　处：《中医临床研究》2024年第8期11-15,共5页Clinical Journal Of Chinese Medicine

基　　金：国家中医药管理局全国中医学术流派传承工作室第二轮建设项目(国中医人教函【2019】62号);江苏省研究生培养创新工程实践创新计划项目(SJCX22-0872)。

摘　　要：目的:挖掘《三因极一病证方论》中治疗头痛的方剂,分析总结归纳其用药规律,以期为临床上头痛的中医治疗提供借鉴和参考。方法:按照纳入标准收集《三因极一病证方论》中治疗头痛的方剂,录入中医传承辅助平台(V2.5),运用软件集成的数据挖掘方法分析其组方用药规律。结果:通过筛选,《三因极一病证方论》中治疗头痛的方剂共68首,包含药物150味。(1)药性以温寒为主,药味以辛、甘、苦为主,主要入脾经、肺经、胃经、心经、肝经、肾经(2)每首方剂中使用药物较少,总使用频次≥5的药物有23味;(3)支持度个数≥10的药物组合有10对,基于关联规则置信度≥0.6的药物组合有13对;关联系数> 0.04的药对有18对;(4)经统计分析得到新处方3个。结论:通过对原文进行数据挖掘,发现《三因极一病证方论》中治疗头痛用药精简且不拘泥于一类,而是从外感、内伤、多脏腑等角度用药,常寒温并用,补泻兼施等。用现代技术挖掘古代文献,不仅为研究古代医学文献提供了新的思路和方法,而且可为临床上头痛的中医治疗提供借鉴和参考。Objective:To excavate the formulas for treating headache in Sanyin Ji Yi Bingzheng Fang Lun(《三因极一病证方论》),analyse and summarize their medication rules,with a view to providing reference for the clinical TCM treatment of headache in the clinic.Methods:According to the inclusion criteria,the prescriptions for treating headache in Sanyin Ji Yi Bingzheng Fang Lun were collected and recorded into the Traditional Chinese Medicine Inheritance Support System(V2.5).The data mining method of software integration was used to analyze the medication rules of the prescriptions.Results:Through screening,there were 68 prescriptions for headache treatment in Sanyin Ji Yi Bingzheng Fang Lun,including 150 drugs.①The drug properties is mainly warm and cold.Tastes of drug are mainly hot,sweet and bitter.These drugs mainly were absorbed by spleen meridian,lungs meridian,stomach meridian,heart meridian,liver meridian and kidney meridian.②Few drugs were used in each prescription,and 23 drugs were used more than 5 times.③There were 10 pairs of drug combinations with support≥10,13 pairs of drug combinations with confidence≥0.6 based on association rules,and 18 pairs of drugs with correlation coefficient>0.04.④Three new prescriptions were obtained by statistical analysis.Conclusion:Through data mining of the original text,it is found that the medicines used in the treatment of headache in the Sanyin Ji Yi Bingzheng Fang Lun are simplified and not confined to one category,but are used from the perspectives of exogenous sensations,internal injuries,and multiple internal organs,and cold medicines are often used with warm medicines,and tonification and purgation methods are used in combination and so on.The use of modern technology to excavate ancient literature not only provides new ideas and methods for the study of ancient medical literature,but also provides reference for the clinical treatment of headache in TCM.

关 键 词：头痛 数据挖掘 用药规律 《三因极一病证方论》 

分 类 号：R441.1[医药卫生—诊断学]