HPA轴及海马BDNF与抑郁症的相关性及柴胡经典方治疗研究进展  

Research Progress on the Correlation of HPA Axis and Hippocampal BDNF with Depression and the Treatment of Bupleurum

作　　者：徐水婷 胡玉英[2] XU Shuiting;HU Yuying(Guangxi University of Chinese Medicine,Nanning,530001 Guangxi,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi,China)

机构地区：[1]广西中医药大学,广西南宁530001 [2]广西中医药大学第一附属医院,广西南宁530023

出　　处：《实用中医内科杂志》2024年第1期28-31,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金项目(81960842);广西高等学校高水平创新团队及卓越学者计划项目(桂教人才[2020]6号);广西中医脑病临床研究中心项目(桂科AD20238028)。

摘　　要：随着当今时代快速发展,抑郁症已成为人类常见病种,以情绪消沉、沉默寡言、思维迟缓等为主症,严重者甚至有自残、自杀的倾向。抑郁症的发病机制复杂,涉及诸多因素。抗抑郁西药种类多,具有一定的疗效,但存在不良反应大、依从性低及易复发等问题,而中药治疗疗效显著。探讨下丘脑-垂体-肾上腺(HPA轴)、海马脑源性神经营养因子(BDNF)与抑郁症的相关性,对柴胡及其经典复方通过调控HPA轴及海马BDNF发挥抗抑郁作用进行综述,以期为临床研发更多具有抗抑郁作用的中药提供理论参考。With the rapid development of the modern era,depression has become a common disease of human beings,with depression,taciturn,slow thinking,sleep disorders as the main symptoms,serious self-harm,suicide.The pathogenesis of de-pression is complex,involving biological,social,psychological and many other factors.There are many kinds of western antide-pressant drugs,which have certain efficacy,but there are problems such as large adverse reactions,low compliance and easy re-currence,while the treatment of traditional Chinese medicine has remarkable efficacy.This study reviewed the correlations be-tween hypothalamus-pituitary-adrenal(HPA axis)and hippocamal brain-derived neurotrophic factor(BDNF)with depres-sion,and antidepressant effects Bupleurum and its classic compound exert through regulating HPA axis and hippocampal BDNF,so as to provide theoretical reference for clinical research and development of more traditional Chinese medicine treatment of de-pression.

关 键 词：下丘脑-垂体-肾上腺 海马BDNF 抑郁症 柴胡 经典复方 

分 类 号：R25[医药卫生—中医内科学]