基于《黄帝内经》“日分四时”理论探讨昼夜节律失衡对甲状腺疾病的影响  

Based on the Theory of"Four Seasons In a Day"in Huangdi Neijing,a Discussion on the Imbalance of Circadian Rhythm Impact of Thyroid Disease

作　　者：李君宇 李双蕾[2] 蒋梦春 孙煜宇 何嘉丽 LI Junyu;LI Shuanglei;JIANG Mengchun;SUN Yuyu;HE Jiali(Guangxi University of Chinese Medicine,Nanning 530001,Guangxi,China;The First Affiliated Hospital to Guangxi University of Chinese Medicine,Nanning 530023)

机构地区：[1]广西中医药大学,广西南宁530001 [2]广西中医药大学第一附属医院,广西南宁530023

出　　处：《实用中医内科杂志》2024年第1期31-33,共3页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家自然科学基金地区基金项目(81860784);中国民族医药学会科研项目(2021Z1141-580302);广西名老中医民族医传承工作室建设项目(桂卫中[2014]9号)。

摘　　要：《黄帝内经》记载:“日分四时”理论,指“春生、夏长、秋收、冬藏”四象的变化于人体一天中生理规律的体现。“日分四时”与昼夜节律理论对于人体在一天中变化的概况高度吻合。昼夜节律失衡导致阴阳失和、气血运行失时,是引起甲状腺疾病反复发作的重要原因,文章基于“日分四时”理论,将昼夜节律失衡对甲状腺疾病反复发作的影响作用进行探讨,认为人体阴阳消长的规律与昼夜节律中各种负反馈调节的变化有互通互用之处,这种互通互用主要表现在随时间推移出现的机体自身调节,是影响甲状腺疾病病情变化的重要因素。昼夜节律失衡使得人体卫气运行障碍,使得人体脏腑经络气机不畅,进一步破坏人体“生长收藏”的功能。其中子时、丑时气血主要流注于肝胆经,基于“日分四时”理论,能为临床治疗瘿病多从肝论治提供一定的理论依据。The theory of"four seasons in a day"in Huangdi Neijing embodies the changes of the four phenomena:sprouting in spring,growth in summer,ripening in autumn,and storage in winter,within the physiological laws of the human body during a day.This theory is highly consistent with the circadian rhythm theory for the human body's daily changes.The disruption of circadian rhythm results in yin-yang disharmony and impaired circulation of qi and blood,contributing significantly to the recur-rence of thyroid disorders.Based on the theory of"four seasons in a day,"this paper explores how imbalanced circadian rhythms can contribute to recurrent thyroid diseases.It is believed that the waxing and waning of yin and yang in the human body are con-nected to changes in various negative feedback regulations within the circadian rhythm.This interoperability is predominantly demonstrated through the body's self-regulation over time,which represents a vital factor affecting the development of thyroid disease.The disruption of circadian rhythm impedes the movement of the body's Defensive Qi,resulting in blockages of internal organs and meridians,thus compromising the functioning of the human body's"Sprouting,Growth,Ripening,and Storage".No-tably,from 11 p.m.to 3 a.m.,Qi and blood predominantly course through the Hepatobiliary Channel.Drawing on the"four seasons in a day"theory,this underscores the theoretical grounding in leveraging liver-focused clinical interventions for treating thyroid diseases.

关 键 词：黄帝内经 日分四时 甲状腺疾病 昼夜节律失衡 负反馈调节 

分 类 号：R265[医药卫生—中医外科学]