中药黄酮类化合物改善脑缺血再灌注损伤的作用及其机制研究进展  

Role of Flavonoids in Traditional Chinese Medicine to Improve Cerebral Ischaemia-reperfusion Injury and Its Mechanism:A Review

作　　者：岳璐 周天豹 闫向丽 苗明三[2,4] 李艳[4] 白明[2,4] YUE Lu;ZHOU Tianbao;YAN Xiangli;MIAO Mingsan;LI Yan;BAI Ming(College of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Academy of Traditional Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China;School of Traditional Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China;Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,郑州450046 [2]河南中医药大学中医药科学院,郑州450046 [3]河南中医药大学中医学院,郑州450046 [4]河南中医药大学豫药全产业链研发河南省协同创新中心,郑州450046

出　　处：《中国实验方剂学杂志》2024年第10期269-279,共11页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82304771);河南省科技攻关项目(222102310623);河南省自然科学基金项目(232300421307)。

摘　　要：脑缺血再灌注损伤(CIRI)的发生率、致残率和病死率极高,严重影响人类生命健康。近年来,现代医学在CIRI诊治方面有一定进展,却依然存在术后康复困难、药物不良反应等问题,CIRI亟需新的治疗药物。中药黄酮类化合物作为一类重要的中药有效成分,其可发挥抗氧化、抑制细胞凋亡、抗炎等药理作用改善脑组织损伤,对提高CIRI患者的生活质量和延缓社会人口老龄化具有重要意义。大量研究发现,中药黄酮类化合物可通过调控细胞表面受体Toll样受体4/核转录因子-κB(TLR4/NF-κB)、磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)、腺苷酸活化蛋白激酶/哺乳动物雷帕霉素靶蛋白(AMPK/mTOR)、Ras同源基因家族成员A/Rho相关卷曲螺旋蛋白激酶(RhoA/ROCK)、核因子E2相关因子2/Kelch样环氧氯丙烷相关蛋白1/血红素加氧酶-1(Nrf2/Keap1/HO-1)、Notch等信号通路,调节脑缺血及再灌注后相关蛋白的转录表达,缓解脑组织损伤的加剧进而改善CIRI。该文分析了近年来国内外的相关文献,对中药黄酮类化合物改善CIRI的作用机制及相关通路进行综述,并在代谢水平上探究CIRI新的治疗方向,旨在为进一步开发和应用中药黄酮类化合物提供依据。Cerebral ischemia-reperfusion injury(CIRI)has a very high incidence,disability,and mortality rates,which seriously affects human life and health.In recent years,modern medicine has made some progress in the diagnosis and treatment of CIRI,but there are still problems such as difficulties in postoperative rehabilitation and adverse drug reactions,and new therapeutic drugs for CIRI are urgently needed.As an important class of active ingredients in traditional Chinese medicine,flavonoids can play antioxidant,apoptosis inhibition,anti-inflammatory,and other pharmacological effects to improve brain tissue damage,which is important for improving the quality of life of CIRI patients and slowing down the aging of the social population.Numerous studies have found that flavonoids in traditional Chinese medicine can regulate cell surface receptors Toll-like receptor 4/nuclear factor-kappaB(TLR4/NF-κB),phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt),adenylate-activated protein kinase/mammalian target of rapamycin protein(AMPK/mTOR),Ras homologous gene family member A/Rho-associated coiled-coil protein kinase(RhoA/ROCK),nuclear factor E2-associated factor 2/Kelch-like epoxychloropropane-associated protein-1/haemoglobin oxygenase 1(Nrf2/Keap1/HO-1),Notch,and other signaling pathways,so as to regulate the transcription and expression of related proteins after CIRI,alleviate brain tissue injury,and improve CIRI.This paper analyzed the relevant literature in China and abroad in recent years,reviewed the mechanism of action and related pathways of flavonoids in traditional Chinese medicine to improve CIRI,and explored the new therapeutic direction of CIRI at the metabolic level,with a view to providing a basis for the further development and application of flavonoids in traditional Chinese medicine.

关 键 词：中药黄酮类 脑缺血再灌注损伤 抗炎 抗氧化 抑制细胞凋亡 

分 类 号：R2-0[医药卫生—中医学] R22R285.5R284R33