基于16S rDNA测序技术探讨地骨皮对自发性高血压大鼠肠道菌群的影响  

Effect of Digupi(Lycii Cortex)on Intestinal Flora in Rats with Spontaneous Hypertension Based on 16S rDNA Sequencing

作　　者：单雨薇 庞童奇 袁媛[1] 陈贺[2] SHAN Yuwei;PANG Tongqi;YUAN Yuan;CHEN He(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;Liaoning Institute of Traditional Chinese Medicine,Shenyang 110034,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁省中医药研究院,辽宁沈阳110034

出　　处：《实用中医内科杂志》2024年第4期1-3,I0001,I0002,共5页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家人力资源和社会保障部留学归国人员择优资助项目(2011LX003);辽宁省博士启动基金项目(20121135);沈阳市中青年高层次创新人才项目(RC180201);沈阳市科技局科学计划项目(F16-205-1-55);沈阳市中青年科技创新人才支持计划项目(RC210297)。

摘　　要：目的探讨地骨皮对自发性高血压大鼠的降压作用及对肠道微生物组成的影响。方法通过16S rDNA测序技术探讨自发性高血压大鼠经地骨皮水提液干预后肠道微生物结构的变化。结果给药后大鼠血压下降,通过测序结果发现拟杆菌门、厚壁菌门等12个生物标志物。结论地骨皮提取物可能通过调节SHR大鼠肠道内菌群的丰度和比值,起到降低血压的效果。Objective To investigate the antihypertensive effect of Digupi(Lycii Cortex)in spontaneous hypertensive rats and the effect on the composition of intestinal microorganisms.Methods The changes of intestinal microbial structure of rats after the intervention of Digupi(Lycii Cortex)were observed through 16S rDNA technology.Result Blood pressure decreased in rats after administration of the drug,and 12 biomarkers such as Bacteroides and Firmicuteswere were identified by sequencing results.Conclusion Digupi(Lycii Cortex)extract exerts a blood pressure lowering effect by modulating the abundance and ration of intestinal flora in SHR rats.

关 键 词：地骨皮 16S rDNA 肠道菌群 自发性高血压 

分 类 号：R285.5[医药卫生—中药学]