儿童泌尿系微生物组与尿路感染的研究进展  

Progress on urinary microbiome and urinary tract infection in children

作　　者：陈檬檬 干意 涂丹娜[2] Chen Mengmeng;Gan Yi;Tu Danna(Medical College,Wuhan University of Science and Technology,Wuhan 430065,China;Department of Pediatrics,Hubei Maternal and Child Health Care Hospital,Wuhan 430070,China)

机构地区：[1]武汉科技大学医学院,430065 [2]湖北省妇幼保健院儿科,武汉430070

出　　处：《国际儿科学杂志》2024年第3期179-182,共4页International Journal of Pediatrics

基　　金：武汉市卫生和计划生育委员会第六批武汉中青年医学骨干人才培养工程项目(2018[116]号)。

摘　　要：尿液并非无菌,而是存在着复杂的泌尿系微生物群落,且早在婴儿时期就开始建立并随年龄逐渐完善。不同年龄阶段、性别泌尿系微生物组有很大的差异,目前,关于儿童核心泌尿系微生物组尚未达成共识。泌尿系微生物组在维持尿路上皮完整、减少病原菌过度生长以及局部免疫功能方面具有重要意义,微生物多样性和组成的变化与泌尿系多种疾病相关,尤其在尿路感染(urinary tract infection,UTI)中。近年针对儿童泌尿系微生物组以及微生物组与UTI之间的关系研究不断加深,因此,该文旨在综述儿童泌尿系微生物组及其在UTI中的作用,并总结干预、重塑儿童泌尿系微生物组来预防再发性尿路感染(recurrent urinary tract infection,rUTI)的方法。Urine is not sterile but contains a complex urinary microbiome that is established as early as infancy and gradually refines with age.There are great differences in urinary microbiome of different ages and gender.At present,the core urinary microbiome of children has not reached a consensus.The urinary microbiome plays an important role in maintaining the integrity of urothelium,reducing the overgrowth of pathogenic bacteria,and local immune function.Changes in microbial diversity and composition are associated with various diseases of the urinary system,especially in urinary tract infections.In recent years,research on the relationship between urinary microbiome composition,microbiome,and urinary tract infection in children has been deepening.Therefore,this review aims to provide an overview of the urinary microbiome and its role in urinary tract infection in children,and to summarize the methods of intervening and reshaping the urinary microbiome in children to prevent recurrent urinary tract infections.

关 键 词：儿童 泌尿系微生物组 尿路感染 再发性尿路感染 

分 类 号：R726.9[医药卫生—儿科]