单核细胞趋化蛋白-1、白细胞介素-18、超敏C反应蛋白、可溶性髓系细胞触发受体-1联合检测对急性上呼吸道感染患儿的早期诊断价值  

Early diagnostic value of monocyte chemotactic protein-1,interleukin-18,hypersensitive C-reactive protein and soluble myeloid cell trigger receptor-1 in children with acute upper respiratory tract infection

作　　者：段慧慧 程蒙 付永娟 蔡艳丽 Duan Huihui;Cheng Meng;Fu Yongjuan;Cai Yanli(Department of Laboratory Medicine,Pingdingshan the Second People′s Hospital,Pingdingshan 467000,China;Department of Pediatrics,Pingdingshan the Second People′s Hospital,Pingdingshan 467000,China)

机构地区：[1]平顶山市第二人民医院检验科,平顶山467000 [2]平顶山市第二人民医院儿科,平顶山467000

出　　处：《中国临床实用医学》2024年第1期34-39,共6页China Clinical Practical Medicine

基　　金：河南省医学科技攻关联合共建项目(LHGJ20217445)。

摘　　要：目的探讨单核细胞趋化蛋白-1(MCP-1)、白细胞介素-18(IL-18)、可溶性髓系细胞触发受体-1(sTREM-1)、超敏C反应蛋白(hs-CRP)水平联合检测对急性上呼吸道感染患儿的早期诊断价值。方法本研究为回顾性病例对照研究,选取2022年1月至2023年3月平顶山市第二人民医院儿科收治的76例急性上呼吸道感染患儿作为观察组,男42例,女34例,年龄(8.54±1.17)岁,年龄范围为5~12岁;选取76名同期健康体检儿童作为对照组,男44名,女32名,年龄(8.82±1.42)岁,年龄范围为6~14岁。比较两组小儿的血清MCP-1、IL-18、hs-CRP、sTREM-1水平;分析血清MCP-1、IL-18、hs-CRP、sTREM-1水平与急性上呼吸道感染的相关性,血清MCP-1、IL-18、hs-CRP、sTREM-1水平联合检测对急性上呼吸道感染患儿的早期诊断效能,以及血清MCP-1、IL-18、hs-CRP、sTREM-1高水平患儿发生急性上呼吸道感染的危险度。结果观察组MCP-1、IL-18、hs-CRP、sTREM-1水平[(185.46±23.57)pg/ml、(124.17±13.68)ng/L、(14.18±1.57)mg/L、(39.17±5.21)pg/ml]高于对照组[(61.35±11.49)pg/ml、(78.25±9.67)ng/L、(3.62±0.79)mg/L、(6.28±2.04)pg/ml],差异有统计学意义(P<0.05)。MCP-1、IL-18、hs-CRP、sTREM-1水平与急性上呼吸道感染均呈正相关(P<0.05);MCP-1、IL-18、hs-CRP、sTREM-1水平升高为急性上呼吸道感染发生的独立危险因素(P<0.05);MCP-1、IL-18、hs-CRP、sTREM-1水平联合检测诊断急性上呼吸道感染患儿的曲线下面积为0.803,灵敏度为93.42%,均明显高于血清MCP-1、IL-18、hs-CRP、sTREM-1水平单独检测结果(P<0.05)。MCP-1、IL-18、hs-CRP、sTREM-1高水平患儿发生急性上呼吸道感染危险度是低水平的2.772倍、2.365倍、1.611倍、1.894倍(P<0.05)。结论MCP-1、IL-18、hs-CRP、sTREM-1水平与急性上呼吸道感染的发生均显著正相关,且联合检测对急性上呼吸道感染患儿具有较高的早期诊断效能。Objective To investigate early diagnostic value of monocyte chemotactic protein-1(MCP-1),interleukin-18(IL-18),hypersensitive C-reactive protein(hs-CRP)and soluble myeloid cell trigger receptor-1(sTREM-1)in children with acute upper respiratory tract infection.Methods This study was a retrospective case-control study,a total of 76 children with acute upper respiratory tract infection admitted to the department of Pediatrics of Pingdingshan the Second People′s Hospital from January 2022 to March 2023 were selected as the study group,including 42 males and 34 females,aged(8.54±1.17)years old,ranging from 5 to 12 years old,a total of 76 healthy children were selected as the control group,including 44 males and 32 females,aged(8.82±1.42)years old,ranging from 6 to 14 years old.The serum levels of MCP-1,IL-18,hs-CRP and sTREM-1 were compared between the two groups.To analyze the correlation between serum MCP-1,IL-18,hs-CRP,sTREM-1 levels and acute upper respiratory tract infection.The efficacy of combined detection of serum MCP-1,IL-18,hs-CRP,sTREM-1 levels in the early diagnosis of children with acute upper respiratory tract infection,and the risk of acute upper respiratory tract infection in children with the high levels of serum MCP-1,IL-18,hs-CRP and sTREM-1.Results The levels of MCP-1,IL-18,hs-CRP and sTREM-1 in the study group[(185.46±23.57)pg/ml,(124.17±13.68)ng/L,(14.18±1.57)mg/L,(39.17±5.21)pg/ml]were higher than those in the control group[(61.35±11.49)pg/ml,(78.25±9.67)ng/L,(3.62±0.79)mg/L,(6.28±2.04)pg/ml],the differences were statistically significant(P<0.05).The levels of MCP-1,IL-18,hs-CRP and sTREM-1 were positively correlated with acute upper respiratory tract infection(P<0.05).The elevated levels of MCP-1,IL-18,hs-CRP and sTREM-1 were independent risk factors for acute upper respiratory tract infection(P<0.05).The area under curve of MCP-1,IL-18,hs-CRP and sTREM-1 combined detection was 0.803 and the sensitivity was 93.42%,which were significantly higher than the results of serum MCP-1,IL-

关 键 词：白细胞介素-18 急性上呼吸道感染 单核细胞趋化蛋白-1 可溶性髓系细胞触发受体-1 超敏C反应蛋白 

分 类 号：R725.6[医药卫生—儿科]