变应性鼻炎患者鼻腔分泌物中IL-4、IL-13及骨膜蛋白与患者病情程度的相关性研究  

Correlation of IL- 4, IL-13 with periostin in nasal secretionand disease severity of allergic rhinitis patients

作　　者：古庆家 官佐 石明佳 马悦展 张婷 杨骋 樊建刚 GU Qingjia;GUAN Zuo;SHI Mingjia;MA Yuezhan;ZHANG Ting;YANG Cheng;FAN Jiangang(Department of Otolaryngology Head and Neck Surgery,Sichuan Academy of Medical Sciences,Sichuan Provincial People’s Hospital,Affiliated Hospital of University of Electronic Science and Technology of China,Chengdu 610072,China;De partment of Otolaryngology Head and Neck Surgery,Affiliated Hospital of Chengdu University,Chengdu 610081,China;School of Medicine,University of Electronic Science and Technology,Chengdu 610054,China)

机构地区：[1]四川省医学科学院,四川省人民医院,电子科技大学附属医院耳鼻咽喉头颈外科,四川成都610072 [2]成都大学附属医院耳鼻咽喉头颈外科,四川成都610081 [3]电子科技大学医学院,四川成都610054

出　　处：《中国耳鼻咽喉颅底外科杂志》2024年第2期19-24,共6页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：四川省科技厅重点研发计划(重大科技专项)(2022YFS0067);电子科技大学中央高校基金(ZYGX2019J110)。

摘　　要：目的 以变应性鼻炎患者的鼻腔分泌物为研究对象,为临床诊断和药物靶点找到新的思路。方法 本研究收集了诊断为变应性鼻炎患者和正常人的鼻腔分泌物,分别采用ELISA法检测样品中白介素-4(IL-4)、白细胞介素-13(IL-13)和骨膜蛋白(POSTN),同时采集样品时采用鼻部症状总评分(TNSS)评价方法评价试验组患者,得出指标量,并进行相关性分析。结果 试验组患者鼻腔分泌物中IL-4、IL-13以及POSTN的含量显著高于正常人(P<0.05),试验组中IL-4、IL-13与POSTN具有显著的相关性(R>0.5)、POSTN与患者发病程度具有显著的相关性(R>0.5)。结论 POSTN似乎在变应性鼻炎的发病机制中起着十分重要的作用,IL-4和IL-13在诱发变应性鼻炎时可能会合成POSTN,且与患者的症状密切相关。检测患者鼻腔分泌物POSTN含量,可协助诊断和判定变应性鼻炎的病情程度。Objective To find new ideas for clinical diagnosis and drug targets by exploring the nasal secretions of patients with allergic rhinitis(AR).Methods Nasal secretion samples were collected from patients with AR and normal controls,and interleukin-4(IL-4),interleukin-4(Il-13)and periostin(POSTN)in the samples were detected by enzyme-linked immunosorbent assay.Meanwhile,total nasal symptom score in the AR patients was obtained as an evaluation index,and correlation analysis was carried out subsequently.Results The levels of IL-4,IL-13 and POSTN in the nasal secretion of AR patients were significantly higher than those of the normal controls(P<0.05).There were significant correlations between IL-4,IL-13 and POSTN(R>0.5),as well as between POSTN and the degree of AR(R>0.5).Conclusions POSTN plays an important role in the pathogenesis of AR.IL-4 and IL-13 can induce the synthesis of POSTN in AR patients,and are closely related to the AR symptoms.Detection of POSTN level in nasal secretion can help diagnose and determine the severity of symptoms in patients with AR.

关 键 词：变应性鼻炎 鼻腔分泌物 骨膜蛋白 IL-4 IL-13 病情程度 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]