川崎病合并冠状动脉病变患者血清Ang-1、YKL-40水平与凝血功能、炎症反应的相关性  

Correlation of serum Ang-1 and YKL-40 levels with coagulation function and inflammatory response in patients with Kawasaki's disease complicated with coronaryartery lesion

作　　者：王帧 张帅[2] 许哲 WANG Zhen;ZHANG Shuai;XU Zhe(Blood Transfusion Department,Children's Hospital Affiliated to Zhengzhou University,Zhengzhou,Henan 450053,China;Laboratory Department,Children's Hospital Affiliated to Zhengzhou University,Zhengzhou,Henan 450053,China)

机构地区：[1]郑州大学附属儿童医院输血科,河南省郑州市450053 [2]郑州大学附属儿童医院检验科,河南省郑州市450053

出　　处：《中国动脉硬化杂志》2024年第5期424-428,共5页Chinese Journal of Arteriosclerosis

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20210672)。

摘　　要：[目的]探究川崎病(KD)合并冠状动脉病变(CAL)患者血清血管生成素1(Ang-1)、人软骨糖蛋白39(YKL-40)水平与凝血功能、炎症反应的相关性。[方法]选取2018年1月—2022年12月收治的90例KD患者作为研究对象,选取同期在本院检查健康的90名儿童为对照组,根据是否合并CAL,分为未合并CAL组(69例)和合并CAL组(21例),比较各组血清Ang-1、YKL-40、凝血功能和炎症因子水平。采用Pearson分析法分析KD合并CAL患者血清Ang-1、YKL-40水平与凝血功能、炎症反应指标的关系,采用多因素Logistic回归分析影响KD患者发生CAL的因素。[结果]对照组、未合并CAL组、合并CAL组血清Ang-1、YKL-40水平比较差异有统计学意义(均P<0.05);随着病情严重程度的增加,对照组、未合并CAL组、合并CAL组血清Ang-1水平逐渐降低,YKL-40水平逐渐升高(均P<0.05)。血清Ang-1与纤维蛋白原(FIB)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、白细胞计数(WBC)呈负相关(均P<0.05),YKL-40与FIB、CRP、TNF-α、IL-6、WBC呈正相关(均P<0.05)。多因素Logistic回归分析显示,YKL-40是影响KD患者并发CAL的危险因素,Ang-1为其保护因素(P<0.05)。[结论]KD合并CAL患者血清Ang-1水平降低、YKL-40水平升高,与凝血功能、炎症反应有一定的相关性。Aim To explore the correlation of serum angiopoietin-1(Ang-1)and human cartilage glycoprotein-39(YKL-40)levels with coagulation function and inflammatory response in patients with Kawasaki's disease(KD)compli-cated with coronary artery lesion(CAL).Methods From January 2018 to December 2022,90 children with KD were selected as the study subjects,and 90 healthy children who were examined in this hospital during the same period were selected as the control group.According to whether CAL was combined,they were divided into non-CAL group(69 cases)and CAL group(21 cases),the levels of serum Ang-1,YKL-40,coagulation function,and inflammatory factors were compared between the two groups.Pearson analysis was used to investigate the relationship between serum Ang-1,YKL-40 levels and coagulation function,inflammatory reaction indicators in children with KD combined with CAL.Multi-variate Logistic regression analysis was used to identify the factors affecting CAL in children with KD.Results There were significant differences in serum Ang-1 and YKL-40 levels among the control group,the non-CAL group and the CAL group(all P<0.05).With the increase of the severity of the disease,the serum Ang-1 level in the control group,the non-CAL group and the CAL group decreased gradually,and the YKL-40 level increased gradually(all P<0.05).Serum Ang-1 was negatively correlated with fibrinogen(FIB),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),in-terleukin-6(IL-6)and white blood cell count(WBC)(all P<0.05),YKL-40 was positively correlated with FIB,CRP,TNF-α,IL-6 and WBC(all P<0.05).Multivariate Logistic regression analysis showed that YKL-40 was a risk factor for CAL in children with KD,and Ang-1 was a protective factor(P<0.05).Conclusion The level of serum Ang-1 de-creased and the level of YKL-40 increased in children with KD complicated with CAL,which was correlated with coagula-tion function and inflammatory response.

关 键 词：川崎病 冠状动脉病变 血管生成素1 人软骨糖蛋白39 凝血功能 炎症反应 

分 类 号：R5[医药卫生—内科学]