Nrf2/HO-1通路在银屑病中作用的研究进展  

Research progress on the role of Nrf2/HO-1 pathway in psoriasis

作　　者：黎敏 龚坚 吴伟伟 刘巧 LI Min;GONG Jian;WU Weiwei;LIU Qiao(Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Jiangxi Provincial Clinical Research Center for Skin Diseases;Department of Plastic and Dermatological Surgery,the Fifth People's Hospital of Hainan Province)

机构地区：[1]江西中医药大学,330004 [2]江西省皮肤病专科医院 [3]海南省第五人民医院整形与皮肤外科

出　　处：《天津医药》2024年第5期552-556,共5页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(81860848);江西省自然科学基金青年基金项目(20232BAB216108);江西省卫生健康委科技计划项目(202311334)。

摘　　要：银屑病的发病机制复杂,探索其发病机制对于治疗十分重要。核因子E2相关因子2(Nrf2)/血红素加氧酶1(HO-1)通路对细胞具有保护作用,与氧化应激、免疫、血管异常增生、表皮失衡以及细胞死亡等生理病理过程密切相关。目前已有研究证实Nrf2/HO-1通路对银屑病皮损有抑制作用,可能通过多种途径参与银屑病发病。就Nrf2/HO-1通路在银屑病中的作用机制及中医药通过干预该通路治疗银屑病的研究进展进行综述。The pathogenesis of psoriasis is complex,so it is very important to explore the pathogenesis for the treatment of psoriasis.The Nrf2/HO-1 pathway has a protective effect on cells and is closely related to physiological and pathological aspects such as oxidative stress,immunity,abnormal proliferation of blood vessels,epidermal imbalance and cell death.Currently,some studies have confirmed that Nrf2/HO-1 pathway may have an inhibitory effect on psoriatic lesion,and it may be involved in psoriasis pathogenesis through multiple pathways.This paper reviews the mechanism of Nrf2/HO-1 pathway in psoriasis and the research progress in the treatment of psoriasis through the intervention of traditional Chinese medicine.

关 键 词：NF-E2相关因子2 血红素加氧酶-1 银屑病 中医药学 氧化性应激 细胞死亡 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]