磺酸化β-环糊精催化合成二苯并[b,i]氧杂蒽四酮  

Synthesis of Dibenzo[b,i]xanthene-tetraones Catalyzed byβ-Cyclodextrin-SO_(3)H

作　　者：李文欢 王英磊[1] 曹春 田野 LI Wen-huan;WANG Ying-lei;CAO Chun;TIAN Ye(School of Biological and Chemical Engineering,Nanyang Institute of Technology,Nanyang 473004,China)

机构地区：[1]南阳理工学院生物与化学工程学院,河南南阳473004

出　　处：《化学试剂》2024年第5期100-105,共6页Chemical Reagents

基　　金：南阳市基础与前沿技术研究计划项目(JCQY007)。

摘　　要：β-环糊精是一种由微生物发酵所生产的环状低聚糖,具有廉价易得、无毒无害、可生物降解等特点。通过β-环糊精和氯磺酸的反应,制备了磺酸化β-环糊精(β-CD-SO_(3)H)。在无溶剂条件下,β-CD-SO_(3)H催化不同取代基的芳香醛与2-羟基-1,4-萘醌反应,以85%~95%的产率合成了一系列13-芳基-5H-二苯并[b,i]氧杂蒽-5,7,12,14(13H)-四酮衍生物。β-CD-SO_(3)H具有制备方法简单、生物相容性优良、回收利用便捷等优点,符合绿色化学的发展方向,具有较好的工业应用前景。β-Cyclodextrin is a cyclic oligosaccharide produced by microbial fermentation.It is well known for its low cost,easily availability,non-toxicity,harmlessness,and biodegradability.β-cyclodextrin-SO_(3)H(β-CD-SO_(3)H)was obtained by reactingβ-cyclodextrin with chlorosulfonic acid.Under solvent-free conditions,β-CD-SO_(3)H catalyzed the reaction between various substituted aromatic aldehyde and 2-hydroxy-1,4-naphthoquinone.This resulted in the synthesis of a series of 13-aryl-5H-dibenzo[b,i]xanthene-5,7,12,14(13H)-tetraone derivatives with yields ranging from 85%to 95%.The advantages ofβ-CD-SO_(3)H include its simple preparation method,excellent biocompatibility,and convenient recyclability.These properties align with the principles of green chemistry and offer promising prospects for industrial applications.

关 键 词：磺酸化β-环糊精 氧杂蒽 绿色化学 重复使用 

分 类 号：O626.3[理学—有机化学]